Results 141 to 150 of about 395,818 (261)

A long-term mouse testis organ culture system to identify germ cell damage induced by chemotherapy. [PDF]

Curr Res Toxicol
Yokota S, Hashimoto K, Sato T, Uemura K, Makiyama K, Nishimura T, Kitajima S, Ogawa T.   +7 more
europepmc   +1 more source

Transcriptional Profiling Provides New Insights into Organ Culture-Induced Changes in Human Donor Corneas. [PDF]

Int J Mol Sci, 2022
Wolf J, Kammrath Betancor P, Maier P, Heinzelmann SU, Jiang J, Lange C, Reinhard T, Schlunck G, Lapp T.   +8 more
europepmc   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Tissue engineered corneal endothelium transplantation in an ex vivo human cornea organ culture model. [PDF]

Sci Rep
Tsai MC, Kureshi A, Daniels JT.
europepmc   +1 more source

Organ Culture Model of Aortic Valve Calcification. [PDF]

Front Cardiovasc Med, 2021
Chester AH, Sarathchandra P, McCormack A, Yacoub MH.   +3 more
europepmc   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Positive Selection by Purified MHC Class II / Thymic Epithelial Cells In Vitro: Costimulatory Signals Mediated by B7 Are Not Involved

Clinical and Developmental Immunology, 1994
Eric J. Jenkinson, Graham Anderson, Nel C. Moore, Christopher A. Smith, John J. T. Owen   +4 more
doaj   +1 more source

Application of testicular organ culture system for the evaluation of spermatogenesis impairment. [PDF]

Sci Rep
Nakagiri H, Ogawa T, Ikeda N, Terasaka S, Nukada Y, Miyazawa M.   +5 more
europepmc   +1 more source

Mammalian Animal and Human Retinal Organ Culture as Pre-Clinical Model to Evaluate Oxidative Stress and Antioxidant Intraocular Therapeutics. [PDF]

Antioxidants (Basel), 2023
Kropp M, Mohit M, Leroy-Ciocanea CI, Schwerm L, Harmening N, Bascuas T, De Clerck E, Kreis AJ, Pajic B, Johnen S, Thumann G.   +10 more
europepmc   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source