Results 91 to 100 of about 1,426,376 (405)

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs

open access: yesStem Cell Research & Therapy, 2017
Background This study aimed to investigate the tolerogenic mechanisms induced by semimature dendritic cells (smDCs) and regulatory dendritic cells (regDCs) after transplantation of hepatocytes differentiated from mouse embryonic stem cells (ESCs) and to ...
Cheng Zhang   +7 more
doaj   +1 more source

Serum Soluble B Cell-Activating Factor Is a Non-Invasive Biomarker of Antibody-Mediated Rejection in Kidney Allograft With Satisfactory Risk Stratification Performance But Negligible Diagnostic Value

open access: yesFrontiers in Immunology, 2022
ObjectivesB cell-activating factor (BAFF), which is critical in the activation and differentiation of B cells, is a candidate diagnostic and predictive biomarker for antibody-mediated rejection (ABMR).
Shenghui Wu   +22 more
doaj   +1 more source

Cultural barriers to organ donation among Chinese and Korean individuals in the United States: a systematic review

open access: yesTransplant International, 2019
Asian Americans have the lowest organ donation registration rates in the United States, and the reason for this is incompletely understood. Aiming to understand the reasons for low organ donation registration rate among Asian Americans, more specifically
Miah T. Li   +3 more
semanticscholar   +1 more source

"You have to die first": exploring the thoughts and feelings on organ donation of British women who have not signed up to be donors [PDF]

open access: yes, 2016
Four White British women who had not signed up to be organ donors were interviewed in depth to investigate their feelings on organ donation. Transcripts were analysed using Interpretative Phenomenological Analysis to reveal how the ability to detach from
Britton, Heather P.   +2 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Obstacles to organ donation

open access: yesJournal of British Surgery, 1989
Abstract Attitudes towards transplantation were investigated in national surveys of the general public (n = 1471), the medical profession (n = 590) and key clinical staff in units referring potential organ donors (n = 380). A clear majority of doctors would like to see more transplants.
R E, Wakeford, R, Stepney
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Short-term impact of introducing a soft opt-out organ donation system in Wales: before and after study

open access: yesBMJ Open, 2019
Objectives To determine the short-term impact of a soft opt-out organ donation system on consent rates and donor numbers. Design Before and after observational study using bespoke routinely collected data.
J. Noyes   +7 more
semanticscholar   +1 more source

Organ Donation: Gauging Perception, Interest, and Clarifying Misconceptions [PDF]

open access: yes, 2017
Around 120,000 people currently need a lifesaving organ transplant in the United States. On average, 22 people die each day while waiting for a life-saving organ transplant. In 2011, over $34 billion dollars were spent on dialysis patients with end-stage
Huynh, Tridu
core   +1 more source

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