Results 71 to 80 of about 543,949 (257)

Patient-adapted organ absorbed dose and effective dose estimates in pediatric 18F-FDG positron emission tomography/computed tomography studies

BMC Medical Imaging, 2020
Background Organ absorbed doses and effective doses can be used to compare radiation exposure among medical imaging procedures, compare alternative imaging options, and guide dose optimization efforts.
Brian M. Quinn, Yiming Gao, Usman Mahmood, Neeta Pandit-Taskar, Gerald Behr, Pat Zanzonico, Lawrence T. Dauer   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deep-learning-based Reconstruction Algorithm Increases Reconstruction Quality of Ultralow Tube Voltage and Low-dose Chest CT Images

CT Lilun yu yingyong yanjiu
Objective: Ultralow tube voltage scanning was combined with a deep-learning-based image reconstruction algorithm (ClearInfinity, CI). The impacts of this method on the image quality and organ radiation dose in low-dose chest computed tomography (CT) were
Wentao MA, Yongxian ZHANG, Senlin GUO, Yunfu LIU, Tianliang KANG   +4 more
doaj   +1 more source

In-house-developed phantoms for organ dose measurements using bovine tissues: A comparison study with CT-Expo simulation software

Journal of Radiation and Cancer Research, 2019
Background: Estimating organ dose from computed tomography (CT) procedures is still ongoing. The aim is to reduce induced cancer risk associated with over dose.
Michael Onoriode Akpochafor, Akintayo Daniel Omojola, Rachel Ibhade Obed, Samuel Olaolu Adeneye, Oluwadare Joseph Adewa, Mary-Ann Etim Ekpo   +5 more
doaj   +1 more source

Estimation of Exposure Dose on MDCT Examination -The Measurement of Organ Dose and Effective Dose by Anthropomorphic Phantom-

Japanese Journal of Radiological Technology, 2010
In order to evaluate the exposure dose in CT examinations, we measured the tissue and organ doses by test site in 4-row, 16-row, and 64-row multi detector CT by using an anthropomorphic phantom and fluorescent glass dosimeters. Furthermore, we calculated the effective dose by using the tissue weighting factor recommended by the ICRP in 2007.
Hirata, Takumi, Inoue, Kenji, Shigemori, Shinji, Matsuzaki,, Michitaka, Inatomi, Kouji   +4 more
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation of Organ Dose Estimation from Indices of CT Dose Using Dose Index Registry

Japanese Journal of Radiological Technology, 2018
Direct measurement of each patient organ dose from computed tomography (CT) is not possible. Most methods to estimate patient organ dose is using Monte Carlo simulation with dedicated software. However, dedicated software is too expensive for small scale hospitals. Not every hospital can estimate organ dose with dedicated software.
Akiko, Iriuchijima, Yasuhiro, Fukushima, Akio, Ogura   +2 more
openaire   +3 more sources