Results 81 to 90 of about 2,193,065 (253)

Syzygy presents Clyde Holloway, organ

open access: yes, 2008
The order of the Paul Cooper and Gunther Schuller works were switched in the actual performanceGMEEORH (1974), Iannis Xenakis -- Requiem (1978) for organ and percussion, Paul Cooper -- Symphony for Organ (1981), Gunther ...

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Effect of small-dose levosimendan on mortality rates and organ functions in Chinese elderly patients with sepsis

open access: yes, 2017
Xin Wang,1,* Shikui Li2,* 1Intensive Care Unit, 2Cardiothoracic Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang, People’s Republic of China *These authors contributed equally to this work Aim: As a primary cause of death not only
Li S, Wang X
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

An international comparison of deceased and living organ donation/transplant rates in opt-in and opt-out systems: a panel study [PDF]

open access: yes, 2014
Background: Policy decisions about opt-in and opt-out consent for organ donation are based on limited evidence. To fill this gap we investigated the difference between deceased and living organ donation rates in opt-in and opt-out consent systems across ...
Ronan E O’Carroll   +6 more
core   +2 more sources

Deep-learning-based Reconstruction Algorithm Increases Reconstruction Quality of Ultralow Tube Voltage and Low-dose Chest CT Images

open access: yesCT Lilun yu yingyong yanjiu
Objective: Ultralow tube voltage scanning was combined with a deep-learning-based image reconstruction algorithm (ClearInfinity, CI). The impacts of this method on the image quality and organ radiation dose in low-dose chest computed tomography (CT) were
Wentao MA   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Patient Dose Estimation Using CT-Expo Software at Two Hospitals in North-Central Nigeria

open access: yesSouthern Clinics of Istanbul Eurasia, 2018
INTRODUCTION[|]Simulation software has aided the estimation of organ dose from computed tomography (CT) examinations. The aim of this study was to use the CT-Expo (SASCRAD, Fritz-Reuter-Weg, Buchholz, Germany) software to determine volume CT dose index ...
Mary-ann Etim Ekpo   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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