Results 1 to 10 of about 4,850,158 (312)

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Critical Care, 2023
The Sequential Organ Failure Assessment (SOFA) score was developed more than 25 years ago to provide a simple method of assessing and monitoring organ dysfunction in critically ill patients.
R. Moreno, A. Rhodes, L. Piquilloud, G. Hernández, J. Takala, H. Gershengorn, M. Tavares, C. Coopersmith, S. Myatra, M. Singer, E. Rezende, H. Prescott, M. Soares, J. Timsit, D. D. de Lange, C. Jung, J. D. De Waele, G. Martin, C. Summers, É. Azoulay, T. Fujii, A. McLean, J. Vincent   +22 more
semanticscholar   +1 more source

Alzheimer’s disease – the journey of a healthy brain into organ failure

Molecular Neurodegeneration, 2022
As the most common dementia, Alzheimer’s disease (AD) exacts an immense personal, societal, and economic toll. AD was first described at the neuropathological level in the early 1900s.
T. Golde
semanticscholar   +1 more source

Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection

JAMA Network Open, 2021
Key Points Question How useful is the neonatal Sequential Organ Failure Assessment for identification of preterm infants at high risk for late-onset, infection-associated mortality?
N. Fleiss, Sarah A. Coggins, A. N. Lewis, Angela C. Zeigler, Krista Cooksey, L. A. Walker, A. Husain, Brenda S de Jong, A. Wallman-Stokes, M. Alrifai, D. Visser, M. Good, B. Sullivan, R. Polin, Camilia R. Martin, J. Wynn   +15 more
semanticscholar   +1 more source

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure [PDF]

, 2015
Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
A O'Riordan, A Turchinovich, AB Imaeda, AM Larson, AM Reddy, B Ekser, Carolina Palacios Jimenez, CD Williams, CL Andersen, D Mladinov, Diego Calvisi, DJ Antoine, E Cholongitas, F Martino, Fausto Andreola, G Szabo, Hatim Alibhai, HT Zhu, J Hellemans, J Vandesompele, JG O'Grady, JK Moore, K John, K Purins, K Wang, Karla C. L. Lee, KC Lee, Lewis PJ Starkey, Luisa A. Baker, M Karali, M Lagos-Quintana, M Weiland, ML Bajt, MR McGill, MW Pfaffl, N Silver, Nathan A. Davies, O Timoneda, O Timoneda, OF Laterza, P Gilje, P Landgraf, Pamela J. Leckie, PS Mitchell, Q Ge, R Bellomo, Rajeshwar P. Mookerjee, Rajiv Jalan, RL Mehta, RT Stravitz, S Bala, T Kawai, W Bernal, WE Hoffman, WM Lee, X Chen, Y Sun, Y Wang, Y Zhang, Yu-Mei Chang, YW Kong   +60 more
core   +9 more sources

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

Inflammation, 2020
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19).
M. Iwasaki, J. Saito, Hailin Zhao, A. Sakamoto, K. Hirota, D. Ma   +5 more
semanticscholar   +1 more source

Impact of Complications After Pancreatoduodenectomy on Mortality, Organ Failure, Hospital Stay, and Readmission

Annals of Surgery, 2020
Supplemental Digital Content is available in the text Objective: To quantify the impact of individual complications on mortality, organ failure, hospital stay, and readmission after pancreatoduodenectomy.
F. Smits, M. Verweij, L. Daamen, C. H. van Werkhoven, L. Goense, M. Besselink, B. Bonsing, O. Busch, R. V. van Dam, C. V. van Eijck, S. Festen, B. Koerkamp, E. van der Harst, I. D. de Hingh, G. Kazemier, J. M. Klaase, M. B. van der Kolk, M. Liem, M. Luyer, M. Meerdink, J. Mieog, V. Nieuwenhuijs, D. Roos, J. M. Schreinemakers, M. Stommel, F. Wit, B. Zonderhuis, V. D. de Meijer, H. V. van Santvoort, I. Molenaar   +29 more
semanticscholar   +1 more source

Association of plasma exosomes with severity of organ failure and mortality in patients with sepsis

Journal of Cellular and Molecular Medicine, 2020
Current sepsis biomarkers may be helpful in determining organ failure and evaluating patient clinical course; however, direct molecular biomarkers to predict subsequent organ failure have not yet been discovered.
Y. Im, H. Yoo, Jin Young Lee, Junseong Park, G. Suh, K. Jeon   +5 more
semanticscholar   +1 more source

The Royal Free Hospital score: a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit. Comparison with current models and CLIF-SOFA score [PDF]

, 2014
Prognosis for patients with cirrhosis admitted to intensive care unit (ICU) is poor. ICU prognostic models are more accurate than liver-specific models.
Agarwal, B, Burroughs, AK, Cheung, M, Cholongitas, E, Mohammad, AO, Pieri, G, Theocharidou, E   +6 more
core   +1 more source

Ringer’s Lactate Prevents Early Organ Failure by Providing Extracellular Calcium

Journal of Clinical Medicine, 2020
Objective: Ringer’s lactate may improve early systemic inflammation during critical illnesses like severe acute pancreatitis, which are associated with hypocalcemia. Ringer’s lactate is buffered and contains lactate and calcium.
Biswajit Khatua, Jordan R. Yaron, Bara El-Kurdi, Sergiy Kostenko, G. Papachristou, Vijay P. Singh   +5 more
semanticscholar   +1 more source

Critical care provision after colorectal cancer surgery [PDF]

, 2016
Background: Colorectal cancer (CRC) is the 2nd largest cause of cancer related mortality in the UK with 40 000 new patients being diagnosed each year. Complications of CRC surgery can occur in the perioperative period that leads to the requirement of ...
Dale, C.D., Kinsella, J., McLoone, P., Morrison, D., Puxty, K., Quasim, T., Sloan, B.   +6 more
core   +1 more source