Results 11 to 20 of about 517,318 (306)

Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

Journal of Hematology & Oncology, 2023
Hyperhomocysteinemia (HHcy) is closely associated with thrombotic diseases such as myocardial infarction and stroke. Enhanced platelet activation was observed in animals and humans with HHcy.
Wenjing Lei, Zhuoliang Liu, Zhiyuan Su, Panpan Meng, Chun Zhou, Xiaomei Chen, Zheng Hu, An Xiao, Miaomiao Zhou, Liping Huang, Yiyue Zhang, Xianhui Qin, Junping Wang, Fengxin Zhu, Jing Nie   +14 more
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Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α

Frontiers in Physiology, 2022
Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or ...
Feifei Xie, Xin Zhen, Xin Zhen, Zhuoliang Liu, Xiaomei Chen, Zhuanhua Liu, Miaomiao Zhou, Zhanmei Zhou, Zheng Hu, Fengxin Zhu, Qiaobing Huang, Lei Zhang, Jing Nie   +12 more
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Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

Frontiers in Physiology, 2019
BackgroundMitochondrial dynamics play a critical role in mitochondrial function. The mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion to maintain and operate the mitochondrial network.
Wenjun Xiong, Wenjun Xiong, Zhuang Ma, Zhuang Ma, Dongqi An, Dongqi An, Zuheng Liu, Zuheng Liu, Wanqiang Cai, Wanqiang Cai, Yujia Bai, Yujia Bai, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +21 more
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Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice

Frontiers in Microbiology, 2017
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that exercise alters the gut microbiota and that modification of the gut microbiota can influence cardiac function.
Zuheng Liu, Zuheng Liu, Hai-Yue Liu, Hai-Yue Liu, Haobin Zhou, Haobin Zhou, Qiong Zhan, Qiong Zhan, Wenyan Lai, Wenyan Lai, Qingchun Zeng, Qingchun Zeng, Hao Ren, Hao Ren, Dingli Xu, Dingli Xu   +15 more
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Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Antisense long noncoding RNAs (lncRNAs) are single‐stranded RNAs that overlapped gene‐coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases.
Bing Li, Yinlan Hu, Xinzhong Li, Guoqing Jin, Xiaoqiang Chen, Guojun Chen, Yanmei Chen, Senlin Huang, Wangjun Liao, Yulin Liao, Zhonghua Teng, Jianping Bin   +11 more
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SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Cell Death and Disease, 2023
Keratinocyte hyperproliferation is a key pathogenic factor in psoriasis. However, the mechanisms that regulate keratinocyte hyperproliferation in this condition remain unclear. Here, we found that SLC35E1 was highly expressed in keratinocytes of patients
Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv, Xiaobo Wang, Yadan Zhong, Hongxin Huang, Xin Zhang, Shufeng Ma, Bin Yang, Xiaohua Wang, Zhili Rong   +12 more
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The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo

Journal of Experimental & Clinical Cancer Research, 2018
Background Multidrug resistance (MDR) is often responsible for the failure of chemotherapy treatment, and current strategies for cancer MDR are not adequately satisfying as to their efficacy and safety.
Chixiong Huang, Senlin Huang, Hairui Li, Xinzhong Li, Bing Li, Lintao Zhong, Junfeng Wang, Meishen Zou, Xiang He, Hao Zheng, Xiaoyun Si, Wangjun Liao, Yulin Liao, Li Yang, Jianping Bin   +14 more
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Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

BMC Medicine, 2023
Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced osteoblastic differentiation in ...
Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng   +8 more
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Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study

Molecular Medicine, 2019
Background 2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acute HF (AHF) is uncertain.
Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng, Dingli Xu   +10 more
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Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

Redox Biology, 2021
Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF).
Dongqi An, Qingchun Zeng, Peijian Zhang, Zhuang Ma, Hao Zhang, Zuheng Liu, Jiaying Li, Hao Ren, Dingli Xu   +8 more
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