Results 21 to 30 of about 4,850,158 (312)

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria*

Critical Care Medicine, 2019
Objectives: Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely recorded in all ...
C. Rhee, Zilu Zhang, S. Kadri, D. J. Murphy, G. Martin, E. Overton, C. Seymour, D. Angus, Raymund B. Dantes, L. Epstein, David M. Fram, Richard Schaaf, Rui Wang, M. Klompas   +13 more
semanticscholar   +1 more source

Altered Hemodynamics and End-Organ Damage in Heart Failure

Circulation, 2020
Heart failure is characterized by pathologic hemodynamic derangements, including elevated cardiac filling pressures (“backward” failure), which may or may not coexist with reduced cardiac output (“forward” failure).
F. Verbrugge, M. Guazzi, J. Testani, B. Borlaug   +3 more
semanticscholar   +1 more source

Acute-on-Chronic Liver Failure: Definition, Diagnosis, and Clinical Characteristics [PDF]

, 2016
Acute-on-chronic liver failure (ACLF) is a recently recognized syndrome in cirrhosis characterized by acute decompensation (AD), organ failure(s), and high short-term mortality.
Arroyo, V, Fernandez, J, Garcia-Tsao, G, Gines, P, Jalan, R, Kamath, PS, Moreau, R, Nevens, F, Schnabl, B, To, U   +9 more
core   +1 more source

Duration of organ failure impacts mortality in acute pancreatitis

Gut, 2019
We read with great interest the recent Gut publication by Schepers et al 1 reporting no association between the time of onset or duration of persistent organ failure (POF, >48 hours, distinguished from transient organ failure  second week) caused by ...
N. Shi, Tingting Liu, Daniel de la Iglesia-García, L. Deng, T. Jin, L. Lan, P. Zhu, Weiming Hu, Zongguang Zhou, Vikesh K. Singh, J. Dominguez-Munoz, J. Windsor, Wei Huang, Q. Xia, R. Sutton   +14 more
semanticscholar   +1 more source

Plasma von Willebrand factor levels predict in-hospital survival in patients with acute-on-chronic liver failure [PDF]

, 2016
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and ...
Amirtharaj, GJ, Balasubramanian, KA, Eapen, CE, Elias, E, Goel, A, Mackie, I, Prasanna, KS, Ramachandran, A, Sajith, KG, Zachariah, U   +9 more
core   +1 more source

A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure.

Pediatric Critical Care Medicine, 2019
OBJECTIVES Ongoing adult sepsis clinical trials are assessing therapies that target three inflammation phenotypes including 1) immunoparalysis associated, 2) thrombotic microangiopathy driven thrombocytopenia associated, and 3) sequential liver failure ...
MD Joseph A. Carcillo, MD Robert A. Berg, MD David Wessel, MD Murray Pollack, MD Kathleen Meert, MD Mark Hall, MD Christopher Newth, MD John C. Lin, MD Allan Doctor, MD Tom Shanley, MD Tim Cornell, MD Rick E. Harrison, MD Athena F. Zuppa, PhD Ron W. Reeder, MS Russell Banks, MD John A. Kellum, PhD Richard Holubkov, MD Daniel A. Notterman, MD J. Michael Dean, E. K. Shriver   +19 more
semanticscholar   +1 more source

Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience

Critical Care Medicine, 2019
Objective: The objective was to compare the resolution of organ dysfunction, 28-day mortality, and biochemical markers in children with thrombocytopenia-associated multiple organ failure who received therapeutic plasma exchange versus no therapeutic ...
J. Fortenberry, Trung C. Nguyen, J. Grunwell, R. Aneja, D. Wheeler, M. Hall, Geoffrey M. Fleming, R. Tarrago, S. Buttram, H. Dalton, Y. Han, Kirk A Easley, A. Knezevic, T. Dai, M. Paden, J. Carcillo   +15 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab [PDF]

, 2010
Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients.
Agarwal, B, Cleverley, JR, Cwynarski, K, Doyle, T, Isaacson, PG, Johns, RH, Lipman, M, Shaw, S   +7 more
core  

Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis [PDF]

, 2017
The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA-REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure.
De Vecchis, Ferrannini, Fitchett, Francis, Greenberg, Hammon, Heise, Heise, Hirose, Lindner, Neal, Peacock, Rabe, Schmieder, Schneider, Schrier, Schrier, Shimizu, Titze, Titze, Titze, Weinfeld, Zinman   +22 more
core   +1 more source