Results 71 to 80 of about 2,772,477 (308)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prevention of organ failure and mortality in decompensated cirrhosis.

, 2016
Decompensated cirrhosis becomes a systemic disease with a dramatic worsening of the prognosis related more to the involvement of other organs rather than to the progressive exhaustion of liver function.
BERNARDI, MAURO, BALDASSARRE, MAURIZIO, CARACENI, PAOLO   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cardiac Myofibroblast‐Derived Small Extracellular Vesicles Moderate Fibrotic Responses via piRNA‐62788/PIWIL2‐Mediated SRF Silencing

Journal of Extracellular Vesicles
During fibrogenesis, certain negative feedback loops are elicited to restrain persistent and hyperactive fibrotic responses. Activated fibroblasts have been found to acquire anti‐fibrotic phenotypes.
Shichao Li, Shuwen Su, Gaopeng Xian, Shunyi Li, Guoheng Zhong, Liming Wen, Dingli Xu, Qingchun Zeng   +7 more
doaj   +1 more source

Long‐Term Estimated Physical Activity Patterns From Youth to Middle Age and Left Ventricular Structure and Function: A 30‐Year Longitudinal Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The long‐term effects of physical activity (PA) variability and cumulative PA (CPA) from young adulthood on cardiac remodeling remain controversial, and it is unclear whether these effects resemble those observed in elite athletes.
Shunyi Li, Jianpin Luo, Shen Zhao, Haobin Zhou, Rongyang Xi, Jun Chen, Shichao Li, Kaiwei Li, Lin Song, Xiaolin Duan, Minhui Xu, Dingli Xu, Qingchun Zeng   +12 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system

Journal of Nanobiotechnology
CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread application. In
Xiaobo Wang, Chengyuan Cai, Weiqi Lv, Kechen Chen, Jiaxin Li, Kaitong Liao, Yanqun Zhang, Hongxin Huang, Ying Lin, Zhili Rong, Xiaopin Duan   +10 more
doaj   +1 more source

Epidemiology of acute kidney injury in hospitalized pregnant women in China

BMC Nephrology, 2019
Background Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and to describe the incidence, risk ...
Diankun Liu, Wenjuan He, Yanqin Li, Mengqi Xiong, Long Wang, Jingxin Huang, Ling Jia, Shuling Yuan, Sheng Nie   +8 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source