Results 261 to 270 of about 62,689 (299)
Leveraging femtosecond laser machining for the fabrication of tubular-based Organ-on-Chip systems: modeling cancer metastasis from invasion to intravasation. [PDF]
Mater Today BioJouybar M +4 more
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Organ-on-chip technology: Opportunities and challenges. [PDF]
Biotechnol NotesSrivastava SK +3 more
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Tissue-on-chip, organ-on-chip, and organism-on-chip
In the preclinical stage of drug development, two- and three-dimensional cell cultures and animal models are used, and these models are insufficient to recapitulate the complexity of human physiology.
Yagmur Filiz, Ozlem Yesil-Celiktas
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Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review
Micromachines, 2020 Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in
Zongzheng Chen, Yao Lu, Tingjiao Liu
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2020
Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
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Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
openaire +2 more sources
Nature Biotechnology, 2014
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular ...
Sangeeta N, Bhatia, Donald E, Ingber
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An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular ...
Sangeeta N, Bhatia, Donald E, Ingber
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Scientific American, 2011
The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
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The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
openaire +2 more sources
2021
Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
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Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
openaire +1 more source