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Microfabrication of human organs-on-chips
Nature Protocols, 2013'Organs-on-chips' are microengineered biomimetic systems containing microfluidic channels lined by living human cells, which replicate key functional units of living organs to reconstitute integrated human organ-level pathophysiology in vitro. These microdevices can be used to test efficacy and toxicity of drugs and chemicals, and to create in vitro ...
Dongeun, Huh +7 more
openaire +2 more sources
2016
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
openaire +1 more source
The process of new drug development is both time and cost intensive. Therefore, all test systems, in particular during the pre-clinical phase, have to provide reliable results to minimize the risk of failure at a later stage of drug development. However, current pre-clinical studies are mainly performed using experimental animals and in vitro cell ...
N. Beißner, T. Lorenz, S. Reichl
openaire +1 more source
Organs-on-a-chip for drug discovery
Current Opinion in Pharmacology, 2013The current drug discovery process is arduous and costly, and a majority of the drug candidates entering clinical trials fail to make it to the marketplace. The standard static well culture approaches, although useful, do not fully capture the intricate in vivo environment.
Seila, Selimović +2 more
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Adoption of organ-on-chip platforms by the pharmaceutical industry
Nature Reviews Drug Discovery, 2021Paul Vulto, Jos Joore, Joore Jos
exaly
Clamping strategies for organ-on-a-chip devices
Nature Reviews Materials, 2023Lorenzo Moroni +2 more
exaly
Organ-on-a-Chip: A New Paradigm for Drug Development
Trends in Pharmacological Sciences, 2021Chao Ma, Yansong Peng, Hongtong Li
exaly
Organ-on-a-chip: A new tool for in vitro research
Biosensors and Bioelectronics, 2022Jiuchuan Guo, Jinhong Guo
exaly
Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication
Trends in Biotechnology, 2021Agnieszka Żuchowska, Severine Le Gac
exaly