Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation
Frontiers in Pharmacology, 2021 Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community.
Min Cao +11 more
doaj +1 more source
Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution [PDF]
, 1993 The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model.
Gasbarrini, A +5 more
core +1 more source
Jurnal Kedokteran Diponegoro, 2021 Background Formaldeyde is main substance used for organ embalming and even for foods preservations. However, long and high exposure of formaldeyhde lead to various organs irritations.
Putri Ariani Kusuma +4 more
doaj +1 more source
Role of perfusion machines in the setting of clinical liver transplantation. A qualitative systematic review [PDF]
, 2018 Growing enthusiasm around machine perfusion (MP) in clinical liver transplantation (LT) may be the preamble for standardized practice to expand the donors' pool.
Lai, Quirino +5 more
core +1 more source
Organ preservation strategies: Review of literature and their applicability in developing nations
South Asian Journal of Cancer, 2014 There has been a change in practice in locally advanced laryngopharyngeal cancers toward non-surgical treatment modalities. Although, there have been landmark trials pertinent to organ preservation, their applicability in developing nations is a topic of
Mitali Dandekar, Anil D′Cruz
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Organ transplantation--then and now. [PDF]
, 1987 The last 25 years have seen amazing progress in transplantation--from the development of techniques for immunosuppression to methods for organ removal and preservation.
Makowka, L, Starzl, TE
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Successful transplantation of porcine liver grafts following 48-hour normothermic preservation.
PLoS ONE, 2017 Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation of liver allografts.
Thomas Vogel +6 more
doaj +1 more source