Results 61 to 70 of about 97,814 (298)

Computer-assisted ex vivo, normothermic small bowel perfusion [PDF]

, 2000
Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena.
Theodorou, D., Hammer, C., Schildberg, Friedrich Wilhelm, Eder, M., Land, W., Stangl, M. J., Krapp, J.   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

New Frontiers in Organ Preservation and Hepatoprotection

, 2022
This editorial aims to summarize the 13 scientific articles published in the Special Issue entitled “New Frontiers in Organ Preservation and Hepatoprotection” [...
Zoltan Czigany, René Hany Tolba, Tolba, René H., Czigany, Zoltan   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A multi-centre randomized controlled trial investigating Consolidation Chemotherapy with and without oxaliplatin in distal rectal cancer and Watch & Wait

BMC Cancer, 2023
Background Neoadjuvant chemoradiation(nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer. Advantages of this approach include improved local control after radical surgery but also the opportunity for organ ...
Angelita Habr-Gama, Guilherme Pagin São Julião, Cinthia D. Ortega, Bruna Borba Vailati, Sergio Araujo, Thiago Jorge, Jorge Sabbaga, Gustavo L. Rossi, Renata D’Alpino, Fabio Roberto Kater, Patricia Bailão Aguilar, Adrian Mattacheo, Rodrigo Oliva Perez, Latin American Rectal Cancer Consortium (LARCC)   +13 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The European Larynx Organ Preservation Study [MK-3475-C44]

Frontiers in Oncology
The European Larynx Organ Preservation Study (ELOS; NCT06137378) is a prospective, randomized, open-label, two-armed parallel group controlled, phase II multicenter larynx organ preservation (LOP) trial in locoregionally advanced (LA) stage III, IVA/B ...
Gunnar Wichmann, Gunnar Wichmann, Theresa Wald, Theresa Wald, Markus Pirlich, Markus Pirlich, Joanna Napp, Ina Münter, Thomas Asendorf, Ralf Tostmann, Jeannette Vogt, Jeannette Vogt, Kathrin Vogel, Kathrin Vogel, Sylvia Meuret, Sylvia Meuret, Matthaeus Stoehr, Matthaeus Stoehr, Veit Zebralla, Veit Zebralla, Nils Henrik Nicolay, Nils Henrik Nicolay, Thomas Kuhnt, Thomas Kuhnt, Peter Hambsch, Peter Hambsch, Orlando Guntinas-Lichius, Orlando Guntinas-Lichius, Jens Peter Klußmann, Susanne Wiegand, Susanne Wiegand, Susanne Wiegand, Andreas Dietz, Andreas Dietz   +33 more
doaj   +1 more source

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.

PLoS ONE, 2019
Various methods have been devised to dissolve hydrogen gas in organ preservation solutions, including use of a hydrogen gas cylinder, electrolysis, or a hydrogen-generating agent.
Eiji Kobayashi, Motoaki Sano
doaj   +1 more source

Organ Preservation in Rectal Cancer

Journal of Gastrointestinal Surgery, 2020
A proportion of patients with rectal cancer who undergo neoadjuvant treatment end up with a complete pathological response. Because these patients have excellent oncological outcomes, many have questioned if surgical treatment in this population constitutes overtreatment. There is growing interest in watch and wait with selective organ preservation for
Jonathan B, Yuval, Hannah M, Thompson, Julio, Garcia-Aguilar   +2 more
openaire   +3 more sources

Organ preservation in pancreas and islet transplantation

, 2008
PURPOSE OF REVIEW: Organ preservation aims at reducing ischemia-reperfusion injury and maintains or even improves its function, and, therefore, increases transplant safety and efficiency.
Baertschiger, Reto Marc, Morel, Philippe, Berney, Thierry   +2 more
core   +1 more source