Results 81 to 90 of about 97,887 (300)

Organ Preservation into the 2020s: The Era of Dynamic Intervention [PDF]

, 2019
Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the ...
Osorio, Juliana Soledad, Fuller, B, Guibert, E, Somov, Alexander, Rodriguez, J, Froghi, F, Petrenko, Alexander, Somov, A, Carnevale, Matías Emanuel, Carnevale, M, Fuller, Barry, Osorio, J, Petrenko, A, Froghi, Farid, Guibert, Edgardo Elvio, Rodríguez, Joaquin   +15 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

New solutions in organ preservation [PDF]

, 2002
Over the last 20 years, a number of methods and solutions have been developed to preserve donor organs for transplantation. Collins et al first introduced the simple cold-storage technique to store and transport kidneys up to 30 hours. The development of
Ploeg, Rutger, 'THart, NA, Leuvenink, HGD, Ploeg, RJ   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Normothermic perfusion: a new paradigm for organ preservation. [PDF]

, 2009
OBJECTIVE: Transplantation of organs retrieved after cardiac arrest could increase the donor organ supply. However, the combination of warm ischemia and cold preservation is highly detrimental to the reperfused organ.
Coussios, C, Hughes, D, Winter, L, Brockmann, J, Roy, D, Friend, PJ, Guirriero, D, Morovat, A, Reddy, S, Friend, Peter, Pigott, D   +10 more
core   +1 more source

The role of metabolomics in current concepts of organ preservation / [PDF]

, 2020
In solid organ transplantation (Tx), both survival rates and quality of life have improved dramatically over the last few decades. Each year, the number of people on the wait list continues to increase, widening the gap between organ supply and demand ...
Kvietkauskas, Mindaugas,, Viktorija Zitkute, Bettina Leber, Philipp Stiegler, Kestutis Strupas, Schemmer, Peter,, Strupas, Kęstutis,, Mindaugas Kvietkauskas, Leber, Bettina,, Žitkutė, Viktorija,, Stiegler, Philipp,, Peter Schemmer   +11 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Fairground Organ Preservation Society Event [PDF]

, 2008
Harry Lee at the Fairground Organ Preservation Society annual general meeting ...
Unknown
core  

Prolonging Preservation or Assessment of Organ Quality—What is Key?

Transplant International, 2023
J. Eden, P. Dutkowski
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source