Results 71 to 80 of about 97,814 (298)

Organ Preservation into the 2020s: The Era of Dynamic Intervention [PDF]

, 2019
Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the ...
Osorio, Juliana Soledad, Fuller, B, Guibert, E, Somov, Alexander, Rodriguez, J, Froghi, F, Petrenko, Alexander, Somov, A, Carnevale, Matías Emanuel, Carnevale, M, Fuller, Barry, Osorio, J, Petrenko, A, Froghi, Farid, Guibert, Edgardo Elvio, Rodríguez, Joaquin   +15 more
core   +1 more source

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

, 2022
20.500.12530/87857The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation.
Hessheimer, Amelia J, Constantino Fondevila, Jordi Vengohechea, Williams, Paul, Lodge, J Peter A, Amelia J. Hessheimer, Javier Salinas, Salinas, Javier, Fondevila, Constantino, Pedro Ramos, Paul Williams, Ramos, Pedro, Vengohechea, Jordi, J. Peter A. Lodge   +13 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Past, present, and future of dynamic kidney and liver preservation and resuscitation

, 2016
The increased demand for organs has led to the increased usage of “higher risk” kidney and liver grafts. These grafts from donation after circulatory death or expanded criteria donors are more susceptible to preservation injury and have a higher risk of ...
Knight, Simon, Brat, Aukje, Pengel, Liset H.M., Knight, S., Nasralla, David, Akhtar, MZ, Pengel, LHM, Akhtar, M. Zeeshan, Jochmans, Ina, Akhtar, M. Z., Kocabayoglu, P., Nasralla, D, Boffa, CJ, Boffa, Catherine J., Pengel, L. H.M.; id_orcid, Kocabayoglu, Peri, O'Callaghan, John, Nasralla, D., O'Callaghan, J., Kaisar, M., O'Callaghan, J, Jochmans, I, Ploeg, R. J., Jochmans, I., Pengel, L. H. M., Boffa, C., Ploeg, RJ, Boffa, Catherine, Ploeg, Rutger, Brat, A., Kaisar, Maria, Brat, A, Knight, S, Kaisar, M, Ploeg, Rutger J., Kocabayoglu, P   +35 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Improved preservation solutions for organ storage: a dynamic study of hepatic metabolism

, 1999
Background. Organ cold storage times may be extended by modifications to organ preservation solutions. Methods. Three preservation solutions were investigated for their ability to maintain viable hepatic bioenergetics in stored pig livers: modified ...
Changani, K.K., Taylor-Robinson, S.D., Fuller, B.J., Davidson, B.R., Bell, J.D., Moore, D.P.   +5 more
core  

Effect of University of Wisconsin organ-preservation solution on haemorheology.

, 2004
In conventional cold-storage organ preservation, the donor organ is flushed with University of Wisconsin (UW) solution at 0-4 degrees C. The initial flush is used to wash out blood from the microcirculation to allow optimal preservation with the UW ...
Ploeg, Rutger, 't Hart, NA, Morariu, AM, Verkerke, GJ, Leuvenink, HGD; id_orcid, Rakhorst, G, van der Plaats, A, Leuvenink, HG, Leuvenink, HGD, Ploeg, RJ, Verkerke, GJ; id_orcid   +10 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Optimizing Organ Donation After Euthanasia: A Critical Appraisal

This Critical Appraisal aims to explore the pharmacokinetics and pharmacodynamics of medications used in organ donors after euthanasia (ODE) and their impact on abdominal organ quality.
H. D. Lam, A. E. Braat, E. A. J. Alkemade, B. J. C. Hendriks, M. J. Coenraad, A. G. Baranski, I. P. J. Alwayn   +6 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source