Results 71 to 80 of about 1,992,155 (390)

Emergent properties of collective gene expression patterns in multicellular systems [PDF]

arXiv, 2021
Multicellular organisms comprise a diverse collection of stable tissues built from different cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue self-organization. We develop a generalized model of multicellular gene expression that includes intracellular and intercellular ...
arxiv  

Organ preservation strategies: Review of literature and their applicability in developing nations

South Asian Journal of Cancer, 2014
There has been a change in practice in locally advanced laryngopharyngeal cancers toward non-surgical treatment modalities. Although, there have been landmark trials pertinent to organ preservation, their applicability in developing nations is a topic of
Mitali Dandekar, Anil D′Cruz
doaj   +1 more source

The Role of Metabolomics in Current Concepts of Organ Preservation

International Journal of Molecular Sciences, 2020
In solid organ transplantation (Tx), both survival rates and quality of life have improved dramatically over the last few decades. Each year, the number of people on the wait list continues to increase, widening the gap between organ supply and demand ...
Mindaugas Kvietkauskas, Viktorija Zitkute, B. Leber, K. Strupas, P. Stiegler, P. Schemmer   +5 more
semanticscholar   +1 more source

Organ preservation surgery for laryngeal cancer [PDF]

, 2009
The principles of management of the laryngeal cancer have evolved over the recent past with emphasis on organ preservation. These developments have paralleled technological advancements as well as refinement in the surgical technique.
A Ferlito, A Gillenwater, AJ McWorther, AN Demiral, Andrew Simon Carney, AS Carney, BA Moore, DA Fein, DH Rice, DSA Braz, EN Myers, FC Holsinger, GS Weinstein, GS Weinstein, GS Weinstein, GS Weinstein, H Laccourreye, HE Eckel, J Haringsma, J Scweinfurth, J Yiotakis, JC Smith, JE Terrell, JE Terrell, JH Ogura, K Apostolopoulos, KM Wilson, KT Brumund, L Rucci, LB Yeager, M Motamed, MG Müller, MS Luscher, MS Persky, NJ Slevin, O Laccourreye, O Laccourreye, O Laccourreye, O Laccourreye, P Ambrosch, P Naudo, PJ Bradley, PW Flint, RK Davis, RO Wein, RP Tufano, Sharad Chawla, SM Cohen, SP Kadish, T Upile, TS Sheen, TY Farrag, WW Mooney   +52 more
core   +2 more sources

Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: role, controversy, and future directions. [PDF]

, 2018
BackgroundThe value of induction chemotherapy (ICT) remains under investigation despite decades of research. New advancements in the field, specifically regarding the induction regimen of choice, have reignited interest in this approach for patients with
Cohen, EEW, Haddad, RI, Hitt, R, Lefebvre, J-L, Posner, M, Schulten, J, Vermorken, JB   +6 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The Process of Organ Donation from Non-Living Donors: A Case-Based Journey from Potential Donor Identification to Organ Procurement [PDF]

, 2018
Each year, thousands of people worldwide succumb to end-organ failure while awaiting life-saving transplantation procedures. The shortage of organs continues with no signs of easing in the foreseeable future. The availability of organs from living donors
Green, Alyssa, Kohler, Scott J., Stahlnecker, Deborah M., Stawicki, Stanislaw P., Sweeney, Joan D., Thomas, Peter G., Wilde-Onia, Rebecca   +6 more
core   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

RAP-Net: Coarse-to-Fine Multi-Organ Segmentation with Single Random Anatomical Prior [PDF]

arXiv, 2020
Performing coarse-to-fine abdominal multi-organ segmentation facilitates to extract high-resolution segmentation minimizing the lost of spatial contextual information. However, current coarse-to-refine approaches require a significant number of models to perform single organ refine segmentation corresponding to the extracted organ region of interest ...
arxiv  

Organ preservation solutions: linking pharmacology to survival for the donor organ pathway [PDF]

, 2018
PURPOSE OF REVIEW: To provide an understanding of the scientific principles, which underpinned the development of organ preservation solutions, and to bring into context new strategies and challenges for solution development against the background of ...
Davidson, B, Froghi, F, Fuller, B
core