Results 81 to 90 of about 276,381 (292)

Treating lupus nephritis patients to lupus low disease activity reduces renal relapse and preserves long‐term kidney function

Arthritis Care &Research, Accepted Article.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE) but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment, and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond YH Yap, KL Lee, Philip H Li, Iris YK Tang, Chak Sing Lau, Shirley CW Chan   +6 more
wiley   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Prolonging Preservation or Assessment of Organ Quality—What is Key?

Transplant International, 2023
J. Eden, P. Dutkowski
doaj   +1 more source

Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys.

PLoS ONE, 2019
BACKGROUND:Since the start of organ transplantation, hypothermia-forced hypometabolism has been the cornerstone in organ preservation. Cold preservation showed to protect against ischemia, although post-transplant injury still occurs and further ...
Hanno Maassen, Koen D W Hendriks, Leonie H Venema, Rob H Henning, Sijbrand H Hofker, Harry van Goor, Henri G D Leuvenink, Annemieke M Coester   +7 more
doaj   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Organ Preservation in Rectal Cancer: The Patients' Perspective

Frontiers in Oncology, 2019
Organ preservation after a clinical complete response to radiochemotherapy is currently one of the most discussed topics in the management of rectal cancer. However, the patients' perspective has only been poorly studied so far. In this multicenter study,
Cihan Gani, Cihan Gani, Cihan Gani, Nina Gani, Sebastian Zschaeck, Fabian Eberle, Norbert Schaeffeler, Thomas Hehr, Bernhard Berger, Stefan Georg Fischer, Johannes Claßen, Stephan Zipfel, Claus Rödel, Martin Teufel, Martin Teufel, Daniel Zips, Daniel Zips   +16 more
doaj   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Linear accelerator-based stereotactic fractionated photon radiotherapy as an eye-conserving treatment for uveal melanoma

Radiation Oncology, 2018
Background The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal melanoma.
Sati Akbaba, Robert Foerster, Nils Henrik Nicolay, Nathalie Arians, Tilman Bostel, Juergen Debus, Henrik Hauswald   +6 more
doaj   +1 more source