Results 291 to 300 of about 116,719 (337)

Endothelial cell toxicity of solid-organ preservation solutions

The Annals of Thoracic Surgery, 1990
Endothelial cell damage caused by myocardial cardioplegic solutions (Bretschneider HTK and St. Thomas' Hospital No. 2) or renal and hepatic cold storage solutions (modified Collins and University of Wisconsin solution) was assessed in monolayer cultures of adult human venous endothelial cells at 4 degrees to 10 degrees C with phase-contrast microscopy.
U O, von Oppell, S, Pfeiffer, P, Preiss, T, Dunne, P, Zilla, B, Reichart   +5 more
openaire   +2 more sources

Kidney preservation in pigs using celsior, a new organ preservation solution

Transplantation Proceedings, 1997
Impact Factor:0 ...
BALDAN N, TOFFANO M, CADROBBI R, CODELLO L, CALABRESE, FIORELLA, BACELLE L, RIGOTTI, PAOLO   +6 more
openaire   +3 more sources

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

Transplantation, 2022
The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs.
Pedro, Ramos, Paul, Williams, Javier, Salinas, Jordi, Vengohechea, J Peter A, Lodge, Constantino, Fondevila, Amelia J, Hessheimer   +6 more
openaire   +2 more sources

New organ preservation solutions.

Kidney international. Supplement, 1992
In 1969 we described a method for kidney preservation that used a brief flush with a new "intracellular" solution followed by ice storage. This paper stimulated research into optimizing solution composition culminating in the UW solution which is now the accepted standard.
G M, Collins, W N, Wicomb
openaire   +1 more source

Infection Transmission Through Organ Preservation Solutions

Infectious Diseases in Clinical Practice
Abstract Organ preservation solutions have become vital for successful transplantation, and with the ever-rising number of transplantations yearly, pathogenic contamination poses a significant threat to the recipient, leading to posttransplant infections and complications.
Shrey Sheladiya, Shreya Patel, HariOm Vaja, Ahan Banker, Sahil Patel   +4 more
openaire   +1 more source

New Solution for Organ Preservation

1990
Two methods are used to preserve organs for clinical transplantation: simple cold storage (CS) and continuous machine perfusion (MP). Simple cold storage uses a flushing solution to replace the blood in the organ and to cool the organ to about 4°C.
openaire   +1 more source

Organ preservation solutions impair deformability of erythrocytes in vitro

Transplantation Proceedings, 2003
Microcirculatory disturbances are observed frequently after restoration of the circulation in transplanted organ. The exact mechanisms responsible for impaired microcirculation during reperfusion are unknown. Erythrocyte deformability is an important factor maintaining the microcirculation.
B, Chmiel, L, Cierpka
openaire   +2 more sources

Organ-Specific Solutions and Strategies for the Intestinal Preservation

International Reviews of Immunology, 2013
Among the intraabdominal organs, the intestine is the most susceptible to storage injury and as a consequence its safe cold ischemic time in the clinic is restricted to below 10 hours. The current practice for the intestinal preservation (IP) consists of an in-situ vascular flush with iced University of Wisconsin or Histidine-Tryptophan-Ketoglutarate ...
Mihai, Oltean, Thomas A, Churchill
openaire   +2 more sources

Inherent toxicity of organ preservation solutions to cultured hepatocytes

Cryobiology, 2008
Organ preservation solutions have been designed to protect grafts against the injury inflicted by cold ischemia. However, toxicity of University of Wisconsin (UW) solution during rewarming has been reported. Therefore, we here assessed the toxicity of UW, histidine-tryptophan-ketoglutarate (HTK), Euro-Collins, histidine-lactobionate (HL), sodium ...
Ursula, Rauen, Herbert, de Groot
openaire   +2 more sources

Drug Development Considerations for Additives to Organ Preservation Solutions

Transplantation
The addition of a novel therapeutic agent to an organ preservation solution has the potential to address unmet needs in organ transplantation and enhance outcomes for transplant recipients. However, the development expectations for novel therapeutic agents in this context are unclear because of limited precedence and published regulatory guidance ...
Matthew, O'Brien Laramy, Jamie, Robinson, C J, Venkatramani, Stephanie, Horn, Carine, Steiner, Yoen-Ju, Son   +5 more
openaire   +2 more sources