Results 271 to 280 of about 116,198 (305)

New Solution for Organ Preservation

1990
Two methods are used to preserve organs for clinical transplantation: simple cold storage (CS) and continuous machine perfusion (MP). Simple cold storage uses a flushing solution to replace the blood in the organ and to cool the organ to about 4°C.
openaire   +1 more source

Organ preservation solutions impair deformability of erythrocytes in vitro

Transplantation Proceedings, 2003
Microcirculatory disturbances are observed frequently after restoration of the circulation in transplanted organ. The exact mechanisms responsible for impaired microcirculation during reperfusion are unknown. Erythrocyte deformability is an important factor maintaining the microcirculation.
B, Chmiel, L, Cierpka
openaire   +2 more sources

Organ-Specific Solutions and Strategies for the Intestinal Preservation

International Reviews of Immunology, 2013
Among the intraabdominal organs, the intestine is the most susceptible to storage injury and as a consequence its safe cold ischemic time in the clinic is restricted to below 10 hours. The current practice for the intestinal preservation (IP) consists of an in-situ vascular flush with iced University of Wisconsin or Histidine-Tryptophan-Ketoglutarate ...
Mihai, Oltean, Thomas A, Churchill
openaire   +2 more sources

Drug Development Considerations for Additives to Organ Preservation Solutions

Transplantation
The addition of a novel therapeutic agent to an organ preservation solution has the potential to address unmet needs in organ transplantation and enhance outcomes for transplant recipients. However, the development expectations for novel therapeutic agents in this context are unclear because of limited precedence and published regulatory guidance ...
Matthew, O'Brien Laramy, Jamie, Robinson, C J, Venkatramani, Stephanie, Horn, Carine, Steiner, Yoen-Ju, Son   +5 more
openaire   +2 more sources

Endothelial cell preservation using organ storage solutions.

Transplantation, 1992
The development of organ preservation solutions has been primarily accomplished in whole organ animal models. This study examines the toxicity of commonly used organ preservation solutions on endothelial cells in vitro. Primary human umbilical-vein endothelial cell cultures were incubated at 4 degrees C in solutions of 0.9% saline (NS), EuroCollins ...
W A, Killinger, D B, Dorofi, B A, Keagy, G, Johnson   +3 more
openaire   +1 more source

Current organ preservation solutions for liver preservation: experimental comparison

Transplantation Proceedings, 2000
R H, Tolba, S, Akbar, U, Puetz, T, Minor
openaire   +2 more sources

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer

Nature Reviews Clinical Oncology, 2021
Emmanouil Fokas, Ane Appelt, Rob Glynne-Jones   +2 more
exaly  

Autooxidation of glutathione in organ preservation solutions

Transplantation Proceedings, 2000
E, Gnaiger, A V, Kuznetsov, A, Königsrainer, R, Margreiter   +3 more
openaire   +2 more sources

IMPROVED PRESERVATION SOLUTIONS FOR ORGAN STORAGE

Transplantation, 1999
K. Kumar Changani, Barry J. Fuller, Jimmy D. Bell, Simon D. Taylor-Robinson, Duncan P. Moore, Brian R. Davidson   +5 more
openaire   +1 more source

Organ preservation with the UW solution

Cryobiology, 1988
J.H. Southard, F.O. Belzer, H.W. Sollinger, M. Kayaloglu, R.M. Hoffmann   +4 more
openaire   +1 more source