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Preservation Solutions for Solid Organ Transplantation

Mini-Reviews in Medicinal Chemistry, 2006
Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.
C H, Wilson, N R, Brook, D, Talbot
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Organ preservation solutions for whole organ pancreas transplantation

Current Opinion in Organ Transplantation, 2011
University of Wisconsin solution is currently the most commonly used solution for abdominal organ transplantation and is the standard to which newer solutions are compared. In recent years, we have witnessed the introduction of two alternative preservation solutions, histidine-tryptophan-ketoglutarate (HTK) solution and Celsior solution, into the ...
Jonathan A, Fridell   +2 more
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CLINICAL ORGAN PRESERVATION WITH UW SOLUTION

Transplantation, 1989
La conservation du foie et du pancreas fait appel a la solution U.W. (University of Niconsin) et a la solution Euro Collins, mais souvent une des variantes. En raison des echanges croissants des organes entre les centres on preconise de reserver le terme «conservation par la solution U.W.» uniquement lorsque la methode originelle est suivie et d ...
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Neo Red Cell as an Organ Preservation Solution

Artificial Cells, Blood Substitutes, and Biotechnology, 1997
Neo red cell (NRC) was derived from outdated human red cells. The following experimental work has been done in order to investigate if NRC is valid for organ preservation. Hearts were obtained from male Lewis rat (250-350 g body weight). Heart transplantation was performed as Ono-Lindsey's method after 1, 3, 6, 12 and 24 hours simple cold storage. Rats
Y, Funakoshi   +4 more
openaire   +2 more sources

Endothelial cell toxicity of solid-organ preservation solutions

The Annals of Thoracic Surgery, 1990
Endothelial cell damage caused by myocardial cardioplegic solutions (Bretschneider HTK and St. Thomas' Hospital No. 2) or renal and hepatic cold storage solutions (modified Collins and University of Wisconsin solution) was assessed in monolayer cultures of adult human venous endothelial cells at 4 degrees to 10 degrees C with phase-contrast microscopy.
U O, von Oppell   +5 more
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Kidney preservation in pigs using celsior, a new organ preservation solution

Transplantation Proceedings, 1997
Impact Factor:0 ...
BALDAN N   +6 more
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Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

Transplantation, 2022
The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs.
Pedro, Ramos   +6 more
openaire   +2 more sources

New organ preservation solutions.

Kidney international. Supplement, 1992
In 1969 we described a method for kidney preservation that used a brief flush with a new "intracellular" solution followed by ice storage. This paper stimulated research into optimizing solution composition culminating in the UW solution which is now the accepted standard.
G M, Collins, W N, Wicomb
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Infection Transmission Through Organ Preservation Solutions

Infectious Diseases in Clinical Practice
Abstract Organ preservation solutions have become vital for successful transplantation, and with the ever-rising number of transplantations yearly, pathogenic contamination poses a significant threat to the recipient, leading to posttransplant infections and complications.
Shrey Sheladiya   +4 more
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