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Macrophages in Organ Transplantation [PDF]

open access: yesFrontiers in Immunology, 2020
Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in ...
Farideh Ordikhani   +5 more
openaire   +4 more sources

Expert consensus on clinical trials of human xenotransplantation in China

open access: yesHealth Care Science, 2022
The history of xenotransplantation started in the 19th century. After a few decades of investigation, significant breakthroughs and preclinical milestones have been achieved worldwide.
Jiefu Huang   +1 more
doaj   +1 more source

Continuous Renal Replacement Therapy in Pediatric Patients With Acute Kidney Injury After Liver Transplantation

open access: yesFrontiers in Pediatrics, 2022
ObjectiveThis study aimed to explore the clinical application of continuous renal replacement therapy (CRRT) in pediatric patients with acute kidney injury (AKI) after liver transplantation.MethodsPediatric patients who underwent liver transplantation ...
Yan Sun   +15 more
doaj   +1 more source

L-carnitine promotes liver regeneration after hepatectomy by enhancing lipid metabolism

open access: yesJournal of Translational Medicine, 2023
Background Lipid metabolism plays an important role in liver regeneration, but its regulation still requires further research. In this study, lipid metabolites involved in mouse liver regeneration at different time points were sequenced and analyzed to ...
Xi Zhou   +8 more
doaj   +1 more source

Impact of donor age on short-term outcomes after pediatric split liver transplantation

open access: yesFrontiers in Pediatrics, 2023
BackgroundDonor shortage is an important limitation of liver transplantation (LT). Split liver transplantation (SLT) may increase the sources of donors and reduce the problem of organ shortage.
Min Xu   +27 more
doaj   +1 more source

Sirolimus in combination with low-dose extended-release tacrolimus in kidney transplant recipients

open access: yesFrontiers in Medicine, 2023
IntroductionMany challenges remain for long-term survival of renal allografts. Once-daily sirolimus (SRL) combined with low-dose extended-release tacrolimus (LER-TAC) may improve medication adherence and reduce the potential nephrotoxicity of calcineurin
Zhi-yu Zou   +12 more
doaj   +1 more source

Bioinformatics analyses on the immune status of renal transplant patients, a systemic research of renal transplantation

open access: yesBMC Medical Genomics, 2020
Background Kidney transplantation is the most effective treatment for end-stage renal disease. Allograft rejections severely affect survivals of allograft kidneys and recipients.
Mei Meng   +8 more
doaj   +1 more source

Liraglutide Attenuates Hepatic Ischemia–Reperfusion Injury by Modulating Macrophage Polarization

open access: yesFrontiers in Immunology, 2022
Ischemia-reperfusion injury (IRI) is a common complication associated with liver surgery, and macrophages play an important role in hepatic IRI. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog primarily used to treat type 2 diabetes and obesity ...
Shang-Lin Li   +22 more
doaj   +1 more source

Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury

open access: yesCell & Bioscience, 2020
Background Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early cell death in the inflammatory ...
Song Zhou   +10 more
doaj   +1 more source

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