Results 141 to 150 of about 517,577 (347)

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease

npj Parkinson's Disease, 2018
During aging, neuronal organelles filled with neuromelanin (a dark-brown pigment) and lipid bodies accumulate in the brain, particularly in the substantia nigra, a region targeted in Parkinson’s disease.
F. Zucca, R. Vanna, F. Cupaioli, C. Bellei, A. de Palma, D. Di Silvestre, P. Mauri, Sara Grassi, A. Prinetti, L. Casella, D. Sulzer, L. Zecca   +11 more
semanticscholar   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Prohibitions in the meta-inflammatory response: a review

Frontiers in Molecular Biosciences
Prohibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
Natalia Todosenko, Kristina Yurova, Maria Vulf, Olga Khaziakhmatova, Larisa Litvinova, Larisa Litvinova   +5 more
doaj   +1 more source

Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]

, 2020
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha, Bhattacharyya, Suvendra N., Bose, Mainak, Chakrabarty, Yogaditya, Chatterjee, Susanta   +4 more
core  

Bovine splenic nerve: characterization of noradrenaline‐containing vesicles and other cell organelles by density gradient centrifugation [PDF]

, 1969
Heide Hörtnagl, Heide Hörtnagl, Hans Winkler   +2 more
openalex   +1 more source

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

Nature Communications, 2018
Despite tremendous efforts to develop stimuli-responsive enzyme delivery systems, their efficacy has been mostly limited to in vitro applications.
T. Einfalt, D. Witzigmann, C. Edlinger, S. Sieber, R. Goers, R. Goers, A. Najer, M. Spulber, O. Onaca-Fischer, J. Huwyler, C. Palivan   +10 more
semanticscholar   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Organelle Targeting Self-Assembled Fluorescent Probe for Anticancer Treatment

Chemosensors
Organic fluorescent probes have attracted attention for bioimaging due to their advantages, including high sensitivity, biocompatibility, and multi-functionality.
Md Sajid Hasan, Sangpil Kim, Chaelyeong Lim, Jaeeun Lee, Min-Seok Seu, Ja-Hyoung Ryu   +5 more
doaj   +1 more source

Markedly different ATP requirements for rRNA synthesis and mtDNA light strand transcription versus mRNA synthesis in isolated human mitochondria [PDF]

, 1987
In isolated mitochondria from HeLa cells, the ATP requirements for mitochondral DNA (mtDNA) transcription and RNA processing can be satisfied by either endogenous synthesis, mainly through oxidative- phosphorylation, or by exogenous supply.
Attardi, Giuseppe, Gaines, George, Rossi, Cesare   +2 more
core  

HYPERTROPHY OF THE AGRANULAR ENDOPLASMIC RETICULUM IN HAMSTER LIVER INDUCED BY PHENOBARBITAL (WITH A REVIEW ON THE FUNCTIONS OF THIS ORGANELLE IN LIVER) [PDF]

, 1966
Albert L. Jones, Don W. Fawcett
openalex   +1 more source