Results 171 to 180 of about 436,875 (327)

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source

Genome-Wide Insights Into the Organelle Translocation of Photosynthetic NDH-1 Genes During Evolution

, 2022
Jie Yu, Zhaoxing Ran, Jingsong Zhang, Lanzhen Wei, Weimin Ma   +4 more
openalex   +1 more source

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Mitochondrial transfer: a Janus-faced force in health and disease. [PDF]

J Transl Med
Hu Y, Zhou W, Chen L.
europepmc   +1 more source

Biosynthesis Of Glyoxysomal Enzymes In Neurospora Crassa [PDF]

, 1982
Flavell R. B., Frevert J., Fritz Miller, Gerhardt B., Herbert Desel, Johanson R. A., Kanarek L., Kindl, KOLLER W., Michael Janes, Mukkerjee A., Novikoff A. B., Richard Zimmermann, Riezman H., Srere P. A., Theimer R. R., Thorne C. J. R., Walter Neupert   +17 more
core   +1 more source

Late-Stage Functionalization of Lysine to Organelle-TargetingFluorescent Probes

Patricia Rodriguez (4715856), Ankita Misra (3593639), Monika Raj (1427989)   +2 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Editorial: Organelles Relationships and Interactions: A Cancer Perspective

Frontiers in Cell and Developmental Biology, 2021
Simone Patergnani, Saverio Marchi, Benjamin Delprat, Mariusz R. Wieckowski   +3 more
doaj   +1 more source

Illuminating the subcellular maze: fluorescence-activated organelle sorting in plant sciences. [PDF]

J Exp Bot
Skalický V, Antoniadi I, Ljung K, Novák O.   +3 more
europepmc   +1 more source