Results 181 to 190 of about 249,615 (265)

Sequence-Modulated Active Tripeptide Condensates for Tandem Catalysis. [PDF]

Angew Chem Int Ed Engl
Han H, Song S, Wang J, Ivanov T, Zhou D, Su H, Landfester K, Cao S.   +7 more
europepmc   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source

Response to the Letter to the Editor. [PDF]

Clin Sci (Lond)
Zouein FA, Booz GW.
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Causes and consequences of cytonuclear incompatibility in hybrids of flowering plants. [PDF]

J Exp Bot
Shahbazi M, Sharbrough J, Knerova J, Wendel JF, Kopecky D.   +4 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

A Generalized Deep Learning Pipeline for Stain-Invariant Ultrastructural Segmentation in Peripheral Nerves. [PDF]

J Imaging
Borisovs V, Cavaletti G.
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

AI driven 3D subcellular RPE map discovers cell state transitions in establishment of apical-basal polarity. [PDF]

NPJ Artif Intell
Ortolan D, Sathe P, Volkov A, Reichert D, Sebastian S, Maminishkis A, Schaub NJ, Ljungquist B, Bose D, Ferrari J, Lin N, Pegoraro G, Simon CG, Sharma R, Bajcsy P, Bharti K.   +15 more
europepmc   +1 more source