The mechanistic links between insulin and human organic anion transporter 4. [PDF]
Int J Pharm, 2019 Wang H, Zhang J, You G.
europepmc +1 more source
Advanced Science, EarlyView.We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi +12 more
wiley +1 more source
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions. [PDF]
Pharmaceutics, 2020 Antonescu IE +8 more
europepmc +1 more source
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Interaction of Anticancer Drugs with Human Organic Anion Transporter hOAT4. [PDF]
J Oncol, 2019 Liu C, Zhang J, You G.
europepmc +1 more source
Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin. [PDF]
Br J Clin Pharmacol, 2020 Bhagunde P +13 more
europepmc +1 more source
Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices
Advanced Science, EarlyView.Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen +9 more
wiley +1 more source
Advanced Science, EarlyView.We report the development of biotinylated PEGylated bilirubin‐coated perfluoropentane (bt‐PEG‐BR@PFP) nanobubbles, a novel class of ROS‐activatable and dual‐modality contrast agents that amplify both ultrasound (US) and magnetic resonance imaging (MRI) signals in response to elevated ROS.
Wonsik Jung +6 more
wiley +1 more source
Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3. [PDF]
AAPS J, 2019 Wang H, Zhang J, You G.
europepmc +1 more source
Advanced Science, EarlyView.A hierarchically porous AOPIM‐CNT electrode enables uranium harvesting from seawater via adsorption‐promoted electrodeposition. Rapid diffusion and selective adsorption are coupled with electrochemical crystallization and spontaneous detachment, creating a self‐refreshing process that sustains high‐capacity, continuous extraction from ultradilute ...
Zejun Song +7 more
wiley +1 more source