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Human Organic Anion Transporter 2 Is Distinct From Organic Anion Transporters 1 and 3 With Respect to Transport Function [PDF]
American Journal of Physiology - Renal Physiology, 2015 Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2, and OAT3 is their ability to transport cGMP. OAT2 interacted with
Yohannes Hagos +2 more
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Renal Transport of Organic Anions and Cations
Comprehensive Physiology, 2011Abstract Organic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic ...
Ryan M, Pelis, Stephen H, Wright
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Renal transport of organic anions
Current Opinion in Nephrology and Hypertension, 1998This review deals with the different transport mechanisms mediating the apical and basolateral transport of organic anions, all of which are restricted to the proximal tubule. Several transport mechanisms, such as the para-aminohippurate basolateral transporter and the apical proton coupled di- and tripeptide transporter have been cloned, and their ...
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FEBS Letters, 2000 A novel organic anion transporting polypeptide (Oatp)4(1) was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)-1 and exhibits a 64% amino acid sequence identity with the human ...
Valentino Cattori +2 more
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Organic Anion Transporters and Their Implications in Pharmacotherapy
Pharmacological Reviews, 2012Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, gender-dependent regulation,
Arian, Emami Riedmaier +3 more
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Transporters for Bile Acids and Organic Anions
2002The liver is one of the most important organs in the detoxification of xenobiotics. Compounds in the circulating blood are taken up by hepatocytes and then are metabolized and/or excreted into the bile. Many kinds of drugs and their metabolites are transported across the sinusoidal and bile canalicular membranes via carriermediated mechanisms.
H, Suzuki, Y, Sugiyama
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Regulation of organic anion transporters
2021The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins ...
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Novel aspects of renal organic anion transporters
Current Opinion in Nephrology and Hypertension, 2003Organic anion transporters, transmembrane proteins present in the renal proximal tubule, are a critical component of the human drug excretion machinery. Recent advances have clarified the function of these transporters, with broad clinical implications for pharmacogenetics, drug interactions and adverse reactions.
Satish A, Eraly +3 more
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Organic Anion Transporters and Organic Anion Transporting Polypeptides
2021Alan Talevi, Carolina L. Bellera
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Regulation of organic anion transporters
2013Human organic anion transporters (hOATs) play critical roles in the body disposition of clinically important drugs. Understanding the regulation of hOATs has profound clinical significance. My thesis work focuses on delineating molecular and cellular mechanisms underlying hOAT regulation, and consists of three parts.
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