Results 261 to 270 of about 26,243 (291)

Organic Anion Transporters and Their Implications in Pharmacotherapy

Pharmacological Reviews, 2012
Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, gender-dependent regulation,
Arian, Emami Riedmaier, Anne T, Nies, Elke, Schaeffeler, Matthias, Schwab   +3 more
openaire   +2 more sources

Role of human organic anion transporter 4 in the transport of ochratoxin A

Biochimica Et Biophysica Acta - Molecular Cell Research, 2002
The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporter 4 (hOAT4) using mouse proximal tubule cells stably transfected with hOAT4 (S2 hOAT4).
Ellappan Babu, Michio Takeda, Shinichi Narikawa   +2 more
exaly   +2 more sources

Transporters for Bile Acids and Organic Anions

2002
The liver is one of the most important organs in the detoxification of xenobiotics. Compounds in the circulating blood are taken up by hepatocytes and then are metabolized and/or excreted into the bile. Many kinds of drugs and their metabolites are transported across the sinusoidal and bile canalicular membranes via carriermediated mechanisms.
H, Suzuki, Y, Sugiyama
openaire   +2 more sources

Hydroxide Anion Transport in Covalent Organic Frameworks

Journal of the American Chemical Society, 2021
Hydroxide anion transport is essential for alkaline fuel cells, but hydroxide anion has an inherently low conductivity owing to its small diffusion coefficient and high mass. Ordered open channels found in covalent organic frameworks are promising as pathways to enable hydroxide anion transport, but this remains to be explored.
Shanshan Tao, Hong Xu, Qing Xu, Yuh Hijikata, Qiuhong Jiang, Stephan Irle, Donglin Jiang   +6 more
openaire   +2 more sources

Regulation of organic anion transporters

2021
The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins ...
openaire   +1 more source

Characterization of ochratoxin A transport by human organic anion transporters

Life Sciences, 2001
The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).
K Y, Jung, M, Takeda, D K, Kim, A, Tojo, S, Narikawa, B S, Yoo, M, Hosoyamada, S H, Cha, T, Sekine, H, Endou   +9 more
openaire   +2 more sources

Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters

European Journal of Pharmacology, 2001
The organic anion transport system is involved in the tubular excretion of various clinically important drugs. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on organic anion transport using proximal tubule cells stably expressing human organic anion transporter 1 (human-OAT1) and human-OAT3 ...
M, Takeda, S, Narikawa, M, Hosoyamada, S H, Cha, T, Sekine, H, Endou   +5 more
openaire   +2 more sources

Novel aspects of renal organic anion transporters

Current Opinion in Nephrology and Hypertension, 2003
Organic anion transporters, transmembrane proteins present in the renal proximal tubule, are a critical component of the human drug excretion machinery. Recent advances have clarified the function of these transporters, with broad clinical implications for pharmacogenetics, drug interactions and adverse reactions.
Satish A, Eraly, Roland C, Blantz, Vibha, Bhatnagar, Sanjay K, Nigam   +3 more
openaire   +2 more sources

Organic anion transport across the choroid plexus

Microscopy Research and Technique, 2000
Several organic anion transport systems have recently been identified and localized at the apical and basolateral plasma membrane domains of choroid plexus epithelial cells. These organic anion transporters include (1) indirectly coupled Na(+)/dicarboxylate cotransport and dicarboxylate/organic anion exchange, which is represented on the molecular ...
Gao, B., Meier, P. J.
openaire   +2 more sources

Hepatocellular Sinusoidal Membrane Organic Anion Transport and Transporters

Seminars in Liver Disease, 1996
This review focuses on oatp, a rat liver protein that has been cloned on the basis of its ability to transport organic anions such as bilirubin and sulfobromophthalein (BSP). Although other proteins have been suggested as having bilirubin or BSP transport activity, these data have primarily been indirect, and their cloning and expression have not yet ...
openaire   +2 more sources