Results 31 to 40 of about 108,823 (192)

Lead Uptake, Toxicity, and Detoxification in Plants [PDF]

, 2011
Lead has gained considerable attention as a persistent toxic pollutant of concern, partly because it has been prominent in the debate concerning the growing anthropogenic pressure on the environment.
Dumat, Camille, Pinelli, Eric, Pourrut, Bertrand, Shahid, Muhammad, Winterton, Peter   +4 more
core   +4 more sources

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Biomolecules, 2020
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H2LR]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HLR)Cl]Cl (1–4) were synthesised with the aim to study (i) their ...
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec, Vladimir B. Arion   +13 more
doaj   +1 more source

High Affinity Decynium-22 Binding to Brain Membrane Homogenates and Reduced Dorsal Camouflaging after Acute Exposure to it in Zebrafish

Frontiers in Pharmacology, 2022
Organic cation transporters (OCTs) are expressed in the mammalian brain, kidney, liver, placenta, and intestines, where they facilitate the transport of cations and other substrates between extracellular fluids and cells.
Georgianna G. Gould, Georgianna G. Gould, Priscilla A. Barba-Escobedo, Priscilla A. Barba-Escobedo, Rebecca E. Horton, Rebecca E. Horton, Lynette C. Daws, Lynette C. Daws, Lynette C. Daws   +8 more
doaj   +1 more source

Evidence for organic cation transporter-mediated metformin transport and 5′-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles [PDF]

Metabolism, 2015
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key molecule of metabolic enhancement in skeletal muscle. We investigated whether metformin (MET) acts directly on skeletal muscle, is transported into skeletal muscle via organic cation transporters (OCTs), and activates AMPK.Isolated rat epitrochlearis and soleus muscles were incubated ...
Oshima, Rieko, Yamada, Mayumi, Kurogi, Eriko, Ogino, Yohei, Serizawa, Yasuhiro, Tsuda, Satoshi, Ma, Xiao, Egawa, Tatsuro, Hayashi, Tatsuya   +8 more
openaire   +2 more sources

Organic Cation Transporter 3 (OCT3) Is Localized to Intracellular and Surface Membranes in Select Glial and Neuronal Cells Within the Basolateral Amygdaloid Complex of Both Rats and Mice [PDF]

, 2016
Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin. OCT3 is expressed widely throughout the
Chan, June, Gasser, Paul J, Hurley, Matthew M., Pickel, Virginia M.   +3 more
core   +2 more sources

Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia [PDF]

, 2013
<p>Background Comparative analysis of tissue-specific transcriptomes is a powerful technique to uncover tissue functions. Our FlyAtlas.org provides authoritative gene expression levels for multiple tissues of Drosophila melanogaster (1).
Chintapalli, V.R., Davies, S.A., Dow, J.A.T., Herzyk, P., Wang, J.   +4 more
core   +2 more sources

Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery

Fluids and Barriers of the CNS, 2023
Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a significant role in regulating post-stroke BBB ...
Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic   +3 more
doaj   +1 more source

Proteolysis-Targeting Chimera (PROTAC) Delivery into the Brain across the Blood-Brain Barrier

Antibodies, 2023
Drug development for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease has challenging difficulties due to the pharmacokinetic impermeability based on the blood-brain barrier (BBB) as well as the ...
Toshihiko Tashima
doaj   +1 more source

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins [PDF]

Drug Metabolism and Disposition, 2015
Atenolol is a β-blocker widely used in the treatment of hypertension. Atenolol is cleared predominantly by the kidney by both glomerular filtration and active secretion, but the molecular mechanisms involved in its renal secretion are unclear. Using a panel of human embryonic kidney cell lines stably expressing human organic cation transporter (hOCT) 1-
Jia, Yin, Haichuan, Duan, Yoshiyuki, Shirasaka, Bhagwat, Prasad, Joanne, Wang   +4 more
openaire   +2 more sources

Functional selectivity of GPCR-directed drug action through location bias. [PDF]

, 2017
G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco, Huang, Bo, Irannejad, Roshanak, Mika, Delphine, Pessino, Veronica, von Zastrow, Mark, Wedegaertner, Philip B.   +6 more
core   +3 more sources