Results 61 to 70 of about 108,823 (192)

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Malaria Journal, 2017
Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink   +7 more
doaj   +1 more source

Tight junction protein ZO-1 controls organic cation/carnitine transporter OCTN2 (SLC22A5) in a protein kinase C-dependent way

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017
OCTN2 (SLC22A5) is an organic cation/carnitine transporter belonging to the solute carrier transporters (SLC) family. OCTN2 is ubiquitously expressed and its presence was shown in various brain cells, including the endothelial cells forming blood-brain barrier, where it was mainly detected at abluminal membrane and in proximity of tight junctions (TJ).
Dominika, Jurkiewicz, Katarzyna, Michalec, Krzysztof, Skowronek, Katarzyna A, Nałęcz   +3 more
openaire   +2 more sources

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
core   +1 more source

Small and mighty: adaptation of superphylum Patescibacteria to groundwater environment drives their genome simplicity. [PDF]

, 2020
BackgroundThe newly defined superphylum Patescibacteria such as Parcubacteria (OD1) and Microgenomates (OP11) has been found to be prevalent in groundwater, sediment, lake, and other aquifer environments.
Adams, Benjamin G, Alm, Eric J, Arkin, Adam P, Detienne, Brittny L, Fields, Matthew W, Gao, Shuhong, Hazen, Terry C, He, Zhili, Joyner, Dominique C, Klingeman, Dawn M, Lowe, Kenneth A, Ning, Daliang, Rocha, Andrea M, Shi, Weiling, Spencer, Sarah J, Stahl, David A, Tian, Renmao, Wu, Linwei, Yang, Yunfeng, Zhang, Ping, Zhang, Ya, Zhou, Jizhong   +21 more
core   +2 more sources

Differential Regulation of Hepatic Organic Cation Transporter 1, Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export Pump, and Multidrug Resistance-Associated Protein 2 Transporter Expression in Lymphocyte-Deficient Mice Associates with Interleukin-6 Production [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2013
Cholestasis results from interrupted bile flow and is associated with immune-mediated liver diseases. It is unclear how inflammation contributes to cholestasis. The aim of this study was to determine whether T and B cells contribute to hepatic transporter expression under basal and inflammatory conditions.
Connor E, Bodeman, Anika L, Dzierlenga, Catherine M, Tally, Ryan M, Mulligan, April D, Lake, Nathan J, Cherrington, Susan C, McKarns   +6 more
openaire   +2 more sources

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]

, 2019
Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T, Nigam, Sanjay K, Rosenthal, Sara Brin   +2 more
core   +1 more source

Mineral Utilization in Rams Fed Ration Supplemented with Different Levels of Chromium, Calcium, and Cation-Anion Balances [PDF]

, 2011
Chromium (Cr) is an essential mineral for ruminants. Its metabolism and interactions with other minerals has not been widely known. This experiment was designed to evaluate the utilization of minerals and growth of Garut ram fed ration supplemented with ...
Amir, F. (F), Arifiantini, R. I. (R), Boediono, A. (A), Permana, I. G. (I), Sudrajat, D. (D), Toharmat, T. (T)   +5 more
core   +3 more sources

Electro-extractive fermentation for efficient biohydrogen production [PDF]

, 2011
Electrodialysis, an electrochemical membrane technique, was found to prolong and enhance the production of biohydrogen and purified organic acids via the anaerobic fermentation of glucose by Escherichia coli. Through the design of a model electrodialysis
Artur J. Majewski, Bisaillon, Clark, Gest, Hallenbeck, Hewitt, KiBeom, Kyazze, Li, Logan, Lugg, Lynne E. Macaskie, Macaskie, Madzingaidzo, Mark D. Redwood, Mondor, Mustacchi, Pal, Pant, Penfold, Rafael L. Orozco, Redwood, Redwood, Redwood, Show, Sinha, Strathmann, Walker, Wang, Warnecke, Wong, Xu, Yoshida, Zaldivar, Zelic   +34 more
core   +1 more source

Fucoidan elevates surface organic cation transporter 2 expression via upregulation of protein kinase A in uric acid nephropathy

Experimental and Therapeutic Medicine, 2017
Uric acid nephropathy (UAN) is caused by excessive uric acid, and is a key risk factor for uric acid nephrolithiasis, gouty arthritis, renal diseases and cardiovascular diseases. The present study aimed to evaluate the protective effect of fucoidan, a sulfated polysaccharide component of brown algae, on UAN and to elucidate the underlying molecular ...
Wu, Xinlin, Yan, Miansheng, Liu, Taoli, Liao, Jiantang, Zhang, Jianqing, Chen, Shuqing, Deng, Wei, Zhang, Shijun, Sun, Baoguo, Zhou, Houming, Ke, Bin   +10 more
openaire   +3 more sources

Correlation of Organic Cation/Carnitine Transporter 1 and Multidrug Resistance-Associated Protein 1 Transport Activities With Protein Expression Levels in Primary Cultured Human Tracheal, Bronchial, and Alveolar Epithelial Cells [PDF]

Journal of Pharmaceutical Sciences, 2016
Understanding how transporters contribute to the distribution of inhaled drugs in the lung is important for the discovery and development of such drugs. Protein expression levels may be useful to predict and understand drug distribution. As previously reported, organic cation/carnitine transporter 1 (OCTN1) and multidrug resistance-associated protein 1
Atsushi, Sakamoto, Shinobu, Suzuki, Takehisa, Matsumaru, Norio, Yamamura, Yasuo, Uchida, Masanori, Tachikawa, Tetsuya, Terasaki   +6 more
openaire   +2 more sources