Results 71 to 80 of about 108,823 (192)

Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters

Frontiers in Bioscience-Landmark
Background: Membrane transport proteins are critical determinants of systemic and intracellular drug levels, thereby contributing substantially to drug response and/or adverse drug reactions. Therefore, the U.S.
Yiwen Wang, Jing Yang, Elke Schaeffeler, Simon U. Jaeger, Matthias Schwab, Anne T. Nies, Bernard Moussian   +6 more
doaj   +1 more source

Evaluation of engineered nanoparticle toxic effect on wastewater microorganisms: current status and challenges [PDF]

, 2013
The use of engineered nanoparticles (ENPs) in a wide range of products is associated with an increased concern for environmental safety due to their potential toxicological and adverse effects.
Coulon, Frederic, Eduok, Samuel, Jefferson, Bruce, Martin, R., Nocker, Andreas, Villa, Raffaella   +5 more
core   +1 more source

Solar-driven carbon dioxide fixation using photosynthetic semiconductor bio-hybrids. [PDF]

, 2019
Solar-driven conversion of carbon dioxide to value-added carbon products is an ambitious objective of ongoing research efforts. However, high overpotential, low selectivity and poor CO2 mass transfer plague purely inorganic electrocatalysts.
Cestellos-Blanco, Stefano, Yang, Peidong, Zhang, Hao   +2 more
core   +1 more source

Data from Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

, 2023
<div>Abstract<p>The drug–drug interaction (DDI) potential of tyrosine kinase inhibitors (TKI) as interacting drugs via transporter inhibition has not been fully assessed. Here, we estimated the half maximal inhibitory concentration (IC₅₀) values for 8 small-molecule TKIs (imatinib, dasatinib, nilotinib, gefitinib ...
Kathleen M. Giacomini, Tsuyoshi Minematsu   +1 more
openaire   +1 more source

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluorinated alkylsulfonic and alkylcarboxylic acids [PDF]

, 2009
Organic carbon normalized soil and sediment-water partitioning (Koc) coefficients were estimated for all C1 through C8 perfluorinated alkylsulfonic acid (PFSA) and alkylcarboxylic acids (PFCA) congeners.
Kaya Forest, Sierra Rayne
core   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

Frontiers in Chemistry, 2018
The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated.
Sarah Spreckelmeyer, Sarah Spreckelmeyer, Margot van der Zee, Benoît Bertrand, Benoît Bertrand, Ewen Bodio, Stefan Stürup, Angela Casini, Angela Casini   +8 more
doaj   +1 more source

Environmental stress responses in Lactococcus lactis [PDF]

, 1999
Bacteria can encounter a variety of physical conditions during their life. Bacterial cells are able to survive these (often adverse) conditions by the induction of specific or general protection mechanisms. The lactic acid bacterium Lactococcus lactis is
Kok, Jan,, Sanders, Jan Willem,, Venema, Gerard,   +2 more
core   +3 more sources

Multi-heme Cytochromes in Shewanella oneidensis MR-1:Structures, functions and opportunities [PDF]

, 2015
Multi-heme cytochromes are employed by a range of microorganisms to transport electrons over distances of up to tens of nanometers. Perhaps the most spectacular utilization of these proteins is in the reduction of extracellular solid substrates ...
Brown JP, Collins MJ, Coursolle D, Fonseca BM, Jochen Blumberger, Julea N. Butt, Kevin M. Rosso, Marian Breuer, Song Y, Teixeira M   +9 more
core   +1 more source

Exploring the cellular accumulation of metal complexes [PDF]

, 2010
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell.
Barton, Jacqueline K., Ernst, Russell J., Puckett, Cindy A.   +2 more
core   +1 more source