Results 31 to 40 of about 257,657 (260)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Machine learning-assisted quantitative prediction of thermal decomposition temperatures of energetic materials and their thermal stability analysis

open access: yesEnergetic Materials Frontiers
In this study, machine learning (ML)-assisted regression modeling was conducted to predict the thermal decomposition temperatures and explore the factors that correlate with the thermal stability of energetic materials (EMs).
Zhi-xiang Zhang   +6 more
doaj   +1 more source

Synthesis and biological evaluation of new benzofuran carboxamide derivatives

open access: yesJournal of Saudi Chemical Society, 2017
A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(β-alanamido)-benzofuran-2-carboxamide derivatives (5a–o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial ...
Andiappan Lavanya   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Chemical exposures in recently renovated low-income housing: Influence of building materials and occupant activities

open access: yesEnvironment International, 2017
Health disparities in low-income communities may be linked to residential exposures to chemicals infiltrating from the outdoors and characteristics of and sources in the home.
Robin E. Dodson   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biomass - Renewable Feedstock for Organic Chemicals ( [PDF]

open access: yesKemija u Industriji, 2009
Limited resources compel us to turn to renewable sources, new and old, that are capable of supporting sustainable development of the human society, and satisfying the demand in energy and materials.
V. P. Kukhar
doaj  

Facile Preparation and Functionalization of Cellulose Microgels and their Properties and Application in Stabilizing O/W Emulsions

open access: yesBioResources, 2016
The preparation and functionalization of cellulose microgels (CMGs) has been presented. Only a trace concentration of CMGs (< 0.2 wt.%) stabilized oil-in-water (O/W) emulsions and produced high internal phase emulsions (HIPE).
Caihong Zhang   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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