Results 51 to 60 of about 1,800,963 (373)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Arbuscular mycorrhizal fungi in organic systems [PDF]

, 2004
Arbuscular mycorrhizal fungi (AMF) are potential contributors to plant nutrition and pathogen suppression in low input agricultural systems, although individual species of AMF vary widely in their functional attributes.
Bending, Gary, Goodlass, G, Gosling, Paul, Hodge, A   +3 more
core  

Sources and Secondary Production of Organic Aerosols in the Northeastern United States during WINTER [PDF]

, 2018
Most intensive field studies investigating aerosols have been conducted in summer, and thus, wintertime aerosol sources and chemistry are comparatively poorly understood.
Apel, E. C., Blake, N. J., Brown, S. S., Campos, T., Campuzano-Jost, P., Day, D. A., Dibb, Jack E., Fibiger, D. L., Guo, H., Hayes, P. L., Hills, A., Hornbrook, R. S., Jaegle, L., Jimenez, J. L., Larson, K., McDuffie, E. E., Reeves, J. M., Scheuer, Eric M., Schroder, J. C., Shah, V., Sommers, J. M., Sullivan, A. P., Thornton, J. A., Weber, R. J.   +23 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

50th Anniversary Perspective: Living Polymerization—Emphasizing the Molecule in Macromolecules [PDF]

, 2017
The ideal of living polymerization has defined research in polymer chemistry over the past 50 years. In this Perspective, we present the case that this concept has enabled the treatment of polymers as organic molecules, rather than impure mixtures of ...
Grubbs, Robert B., Grubbs, Robert H.
core  

Tamoxifen-like metallocifens target thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells [PDF]

, 2017
Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved
Alberto Bindoli, Alessandra Folda, Anne Vessières, Gérard Jaouen, Hui Zhi Shirley Lee, Maria Pia Rigobello, Michèle Salmain, Pascal Pigeon, Siden Top, Valeria Scalcon   +9 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Synthesis, Chemistry and Applications of 5-Hydroxymethyl-furfural And Its Derivatives [PDF]

, 2001
The prospect of exciting research activity in the chemistry of furfural derived compounds such as 5-hydroxymethylfurfural (HMF), 2,5-furandicarbaldehyde and 2,5-furan-dicarboxylic acid prompted the writing of this article.
Lewkowski, Jarosław
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Taurine-Based Hybrid Drugs as Potential Anticancer Therapeutic Agents: In Vitro, In Vivo Evaluations

Pharmaceuticals
Background/Objectives: The development of antitumor agents possessing low toxicity against non-cancerous cells is still a challenge in medicinal chemistry. In this paper, we report the antitumor activity of “hybrid structures” derived from the amino acid
Saltanat Nakypova, Andrey Smolobochkin, Tanzilya Rizbayeva, Rakhymzhan Turmanov, Almir Gazizov, Nurgali Akylbekov, Rakhmetulla Zhapparbergenov, Roza Narmanova, Saltanat Ibadullayeva, Alena Zalaltdinova, Marat Syzdykbayev, Julia Voronina, Anna Lyubina, Alexandra Voloshina, Elena Klimanova, Tatiana Sashenkova, Denis Mishchenko, Alexander Burilov   +17 more
doaj   +1 more source