Results 51 to 60 of about 494,571 (318)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Soil Organic Matter Changes in Lithuanian Soils: Experiences and Results [PDF]

open access: yes, 2009
Lithuania, Soil organic matter, Eutric Albeluvisol, Soil conservation, Carbon sequestration, Land management, Crop rotationData has been obtained from sandy loam Eutric Albeluvisol-ABe at the Kaltinenai Research Station of the Lithuanian Institute of ...
Jankauskienė, Genovaitė   +4 more
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Synthesis of quadruply boron-doped acenes with stimuli-responsive multicolor emission

open access: yesNature Communications
Boron-doped acenes have attracted attention due to their unique structures and intriguing luminescent properties. However, the hitherto known boron-doped acenes have only one or two boron atoms, limiting the chemical space of this unique family of ...
Cheng Chen   +4 more
doaj   +1 more source

Mycorrhizal fungi arbuscular in forage grasses cultivated in Cerrado soil

open access: yesScientific Reports, 2022
The Cerrado is one of the most important regions for agricultural development in the world and is the main productive breadbasket of the Americas. One of the main agricultural activities in the region is high-tech livestock.
Leidiane dos Santos Lucas   +9 more
doaj   +1 more source

Natural organic matter coagulation [PDF]

open access: yes, 2005
The removal of natural organic matter (NOM) is one of the main challenges facing water utilities in both the UK and the US. As a consequence of changes in land management and an increased carbon loss from solids, a greater amount of accumulated ...
Sharp, Emma
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Stereoselective synthesis of tetra- and tri-substituted alkenyl nitriles via aminative ring-opening of cyclopropenes with iron-aminyl radical

open access: yesNature Communications
The ring opening of cyclopropenes provides a compelling platform for the rapid synthesis of various polysubstituted acyclic alkenes. However, radical-mediated reactions of this type remain underexplored, and none of the existing methods have successfully
Qian Wang   +4 more
doaj   +1 more source

Progress in Gliotoxin Research

open access: yesMolecules
Gliotoxin, an important fungal secondary metabolite, belongs to the class of epidithiodiketopiperazines (ETPs) and exhibits various biological activities, including immunosuppression, induction of apoptosis, and antimicrobial, antiviral, and antitumor ...
Longqi Li   +3 more
doaj   +1 more source

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