Results 1 to 10 of about 4,308 (256)

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues

Molecules, 2023
Compounds with acylhydrazone fragments contain amide and imine groups that can act as electron donors and acceptors, so they are easier to bind to biological targets and thus generally exhibit significant biological activity.
Hongjian Song, Qingmin Wang, Yuxiu Liu   +2 more
exaly   +5 more sources

Acylhydrazones and Their Biological Activity: A Review

Molecules, 2022
Due to the structure of acylhydrazones both by the pharmacophore –CO–NH–N= group and by the different substituents present in the molecules of compounds of this class, various pharmacological activities were reported, including antitumor, antimicrobial ...
Laura-Ileana Socea, Stefania-Felicia Barbuceanu, Elena Mihaela Pahontu, Alexandru-Claudiu Dumitru, George Mihai Nitulescu, Roxana Corina Sfetea, Theodora-Venera Apostol   +6 more
doaj   +3 more sources

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors. [PDF]

ChemMedChem
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Sellitepe HE, Aksel AB, Pehlivanlar Yavrucu E, Zıvalı H, Sağlık Özkan BN, Doğan İS.   +5 more
europepmc   +2 more sources

Exploring Acylhydrazones’ Properties Against Neurodegenerative Diseases and Other Clinical Applications: A Review [PDF]

Pharmaceuticals
Neurodegenerative diseases are a serious problem for modern society, and their treatment remains an important issue discussed by the scientific community.
Julia Skroban, Marta Kruk-Słomka, Łukasz Popiołek   +2 more
doaj   +2 more sources

Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

Molecules, 2019
As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral ...
Pei Li, Zai-Bo Yang
exaly   +3 more sources

Ultrasound-Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis-Macrophage Crosstalk in Diabetic Wound Healing. [PDF]

Adv Sci (Weinh)
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Wang K, Zhuo S, Song B, Chen J, Zhao X, Li S, You S, Jiang D, Chen Y, Dang J, Wang T, Guo B, Yu Z, Song B.   +13 more
europepmc   +2 more sources

Design, Synthesis, and Insecticidal Activity of Some Novel Diacylhydrazine and Acylhydrazone Derivatives

Molecules, 2015
In this study a series of diacylhydrazine and acylhydrazone derivatives were designed and synthesized according to the method of active group combination and the principles of aromatic group bioisosterism.
Jialong Sun, Yuanming Zhou
exaly   +3 more sources

Discovery of Bacillamide–Acylhydrazone Hybrids as Novel Fungicide Lead Compounds [PDF]

Journal of Fungi
To identify fungicide lead compounds with novel scaffolds and high efficacy, 33 novel bacillamide–acylhydrazone derivatives were successfully designed and synthesized by using a molecular hybridization strategy.
Sijia Feng, Yuxiao Zhang, Peipei Shi, Ke Chen, Kang Lei   +4 more
doaj   +2 more sources

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives [PDF]

Molecules, 2014
A series of 14 (E)-cinnamic N-acylhydrazone derivatives, designed through molecular hybridization between the (E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-bromophenyl)prop-2-en-1-one and (E)-3-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)-7-methoxy-2-naphthohydrazide, were tested for in vitro antiparasitic activity upon axenic amastigote forms of ...
Carlos Alberto Manssour Fraga, Samir Aquino Carvalho, Marcel Kaiser   +2 more
exaly   +5 more sources

Synthesis and characterization of Molybdenum(VI) complex with 4-methoxy Salicylaldehyde 2-aminobenzoylhydrazon and investigation of their antibacterial activity [PDF]

شیمی کاربردی روز, 2021
In the study, reaction of the 4-methoxy salicylaldehyde 2-aminobenzoylhydrazone(H2L) with MoO2(acac)2 formed a 5-coordinate Molybdenum(VI) complex [MoO2L].
Mahboobeh Moosavi, Niaz Monadi, Mojtaba Mohseni   +2 more
doaj   +1 more source