Results 21 to 30 of about 1,339 (180)
Global Challenges, 2019 Gel adsorbents are promising for pollutant removal from the wastewater. Herein, an acylhydrazone gel is developed from acylhydrazide‐terminated pentaerythritol (PAT) and 2,4,6‐triformylphloroglucinol (TFP) based on dynamic covalent acylhydrazone ...
Haobin Fang +4 more
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Molecules, 2019 As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral ...
Zai-Bo Yang, Pei Li, Yin-Ju He
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Scientific African, 2023 Indole is an exceptional scaffold in the discovery and design of drugs with different mechanisms and biological activity. Numerous research has been conducted on N-acylhydrazones of indole and its derivatives, however, no account of the synthesis ...
Emmanuel Oloruntoba Yeye +3 more
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Química Nova, 2002 In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c.
Eliezer J. Barreiro +3 more
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N′-[1-(Pyrazin-2-yl)ethylidene]pyrazine-2-carbohydrazide
IUCrData, 2018 The title compoud, C11H10N6O, was synthesized by the condensation reaction of pyrazine-2-carbohydrazide with 2-acetylpyrazine in ethanol. The dihedral angle between the pyrazine rings is 4.7 (3)°.
Zhaodong Wang
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Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues
Molecules, 2012 In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug ...
Eliezer J. Barreiro +8 more
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Reactions of N-acylhydrazones with thionyl chloride [PDF]
Arkivoc, 2003 N-Acylhydrazones of o-hydroxyaryl ketones react with thionyl chloride to give Narylhydrazonoyl chlorides in good yields.
Antigoni Kotali, Ioannis S. Lafazanis
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Oral Antithrombotic Effects of Acylhydrazone Derivatives
Journal of Atherosclerosis and Thrombosis, 2013 In the search for new antithrombotic drug candidates, the synthesis and anti-platelet activity of a new series of N-acylhydrazones that were designed as thrombin inhibitors has been previously described. The aim of this work was to further characterize the effects of these compounds on thrombin-induced platelet aggregation and induced thrombosis in ...
Frattani, Flávia Serra +4 more
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(5-Hydroxy-3-methyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl)(2-hydroxyphenyl)methanone
IUCrData, 2016 In the title compound, C12H11F3N2O3, the hydroxyphenyl ring is twisted by 35.42 (11)° from the plane of the pyrazoline ring. The keto O atom is involved in two intramolecular O—H...O hydrogen bonds, which generate S(6) loops.
Kuvondik G. Avezov +4 more
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Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties. [PDF]
PLoS ONE, 2016 LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme, which participates in the activation of the nuclear factor κB (NF-κB) canonical pathway, and its three N-acylhydrazone new analogues, LASSBio-1760, LASSBio-1763 and ...
Natália M Cordeiro +3 more
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