Results 31 to 40 of about 2,678 (221)

Design, Synthesis, and Bioactivities of Novel Tryptophan Derivatives Containing 2,5-Diketopiperazine and Acyl Hydrazine Moieties

Molecules, 2022
Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing 2,5-diketopiperazine and acyl hydrazine moieties have been designed, synthesized, characterized, and evaluated for their biological activities.
Lili Li, Rongxin Yang, Jianhua Liu, Jingjing Zhang, Hongjian Song, Yuxiu Liu, Qingmin Wang   +6 more
doaj   +1 more source

Investigation of Covalent Adaptable Networks ( CANs ) Based on Dynamic Acylhydrazone Bonds Featuring Shape‐Memory Ability

Journal of Applied Polymer Science, Volume 143, Issue 18, May 10, 2026.
Application of dynamic acylhydrazones to achieve CANs with shape‐memory properties. ABSTRACT Covalent adaptable networks (CANs) are based on reversible crosslinks, which are present within the polymer network structure. Due to these reversible moieties, CANs feature interesting properties/abilities such as self‐healing after damage, shape‐memory ...
Farhad Shohraty, Michael Freduah Agyemang, Maike Klein, Stefan Zechel, Michael Schmitt, Jürgen Popp, Martin D. Hager   +6 more
openalex   +2 more sources

Acylhydrazones as Widely Tunable Photoswitches

Journal of the American Chemical Society, 2015
Molecular photoswitches have attracted much attention in biological and materials contexts. Despite the fact that existing classes of these highly interesting functional molecules have been heavily investigated and optimized, distinct obstacles and inherent limitations remain.
Derk Jan van Dijken, † Petr Kovaříček, ‡ Svante P. Ihrig, and Stefan Hecht*   +3 more
openaire   +3 more sources

Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

Molecules, 2019
As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral ...
Zai-Bo Yang, Pei Li, Yin-Ju He
doaj   +1 more source

3-Aminothiophene-2-Acylhydrazones: Non-Toxic, Analgesic and Anti-Inflammatory Lead-Candidates

Molecules, 2014
Different chemotypes are described as anti-inflammatory. Among them the N-acylhydrazones (NAH) are highlighted by their privileged structure nature, being present in several anti-inflammatory drug-candidates.
Yolanda Karla Cupertino da Silva, Christian Tadeo Moreno Reyes, Gildardo Rivera, Marina Amaral Alves, Eliezer J. Barreiro, Magna Suzana Alexandre Moreira, Lídia Moreira Lima   +6 more
doaj   +1 more source

Construction of diazepine-containing spiroindolines via annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates

Beilstein Journal of Organic Chemistry, 2023
A straightforward synthetic protocol for the efficient construction of diazepine-containing spiroindolines has been developed and proceeds through a by base-promoted annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates.
Xing Liu, Wenjing Shi, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations

Anais da Academia Brasileira de Ciências, 2018
New acylhydrazone-based palladacycles are prepared and evaluated as pre-catalysts in Mirozoki-Heck and oxyarylation reactions.
RAQUEL A.C. LEÃO, VAGNER D. PINHO, ARTUR S. COELHO, ARTHUR E. KÜMMERLE, PAULO R.R. COSTA   +4 more
doaj   +1 more source

Reactions of N-acylhydrazones with thionyl chloride [PDF]

Arkivoc, 2003
N-Acylhydrazones of o-hydroxyaryl ketones react with thionyl chloride to give Narylhydrazonoyl chlorides in good yields.
Antigoni Kotali, Ioannis S. Lafazanis
openaire   +2 more sources

A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos Medicinal chemistry of N-acylhydrazones: novel lead-compounds of analgesic, antiinflammatory and antithrombotic drugs

Química Nova, 2002
In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c.
Eliezer J. Barreiro, Carlos A. M. Fraga, Ana L. P. Miranda, Carlos R. Rodrigues   +3 more
doaj   +1 more source

In silico studies and antimicrobial investigation of synthesised novel N-acylhydrazone derivatives of indole

Scientific African, 2023
Indole is an exceptional scaffold in the discovery and design of drugs with different mechanisms and biological activity. Numerous research has been conducted on N-acylhydrazones of indole and its derivatives, however, no account of the synthesis ...
Emmanuel Oloruntoba Yeye, Mukaram AkintundeAdeniyi-Akee, Sikiru Akinyeye Ahmed, Sherifat Adeyinka Aboaba   +3 more
doaj   +1 more source