Results 51 to 60 of about 3,211 (225)

Synthesis, crystal structure and bioactivity of phenazine-1-carboxylic acylhydrazone derivatives [PDF]

, 2021
A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine.
Huang, Yali, Liang, Xi, Liu, Hua, Luo, Fang, Redshaw, Carl, Shen, Lingyi, Wu, Ning, Wu, Shouting, Xu, Hong, Yang, Xianjiong, Zhang, Qilong   +10 more
core   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments [PDF]

, 2016
Small-molecule fragments binding to biomacromolecules can be starting points for the development of drugs, but are often difficult to detect due to low affinities.
Arkona, Christoph, Becker, Daniel, Coll, Miquel, Hilgenfeld, Rolf, Kaczmarska, Zuzanna, Rademann, Joerg, Schulz, Robert, Tauber, Carolin, Wolber, Gerhard   +8 more
core   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

Design, Synthesis, and Insecticidal Activity of Some Novel Diacylhydrazine and Acylhydrazone Derivatives

Molecules, 2015
In this study a series of diacylhydrazine and acylhydrazone derivatives were designed and synthesized according to the method of active group combination and the principles of aromatic group bioisosterism.
Jialong Sun, Yuanming Zhou
doaj   +1 more source

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents

Molecules, 2018
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at specific positions on BT scaffold modulate the antitumor property. The potential of BTs encouraged us to synthesize a number of new 2-((
Derya Osmaniye, Serkan Levent, Abdullah Burak Karaduman, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı   +5 more
openaire   +4 more sources

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Incorporating crystalline smart materials to fabricate 4D printed photomechanical actuators with photovoltaic performance [PDF]

Smart Mol
A versatile 4D printed approach was developed to fabricate complex and refined photomechanical actuators using crystalline materials, including molecular crystals and covalent organic frameworks. The prepared smart actuators exhibited outstanding photomechanical and photovoltaic performance.
Liu Y, Liu J, Hao L, Lin E, Wang J, Wang T, Geng S, Cheng P, Zhang Z.   +8 more
europepmc   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Antifungal Activity of Acylhydrazone Derivatives against Sporothrix spp.

Antimicrobial Agents and Chemotherapy, 2021
Sporotrichosis is an emerging mycosis caused by members of the genus Sporothrix . The disease affects humans and animals, particularly cats, which play an important role in zoonotic transmission.
Jhon Jhamilton Artunduaga Bonilla, Leandro Honorato, Krupanandan Haranahalli, Isabella Dib Ferreira Gremião, Sandro Antonio Pereira, Allan Guimarães, Andrea Regina de Souza Baptista, Patricia de Melo Tavares, Marcio L. Rodrigues, Kildare Miranda, Iwao Ojima, Maurizio Del Poeta, Leonardo Nimrichter   +12 more
openaire   +3 more sources