Results 51 to 60 of about 2,678 (221)

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

Identification of a strong and specific antichlamydial N-acylhydrazone

PLOS ONE, 2017
Sexually transmitted Chlamydia trachomatis is an extremely common infection and often leads to serious complications including infertility and pelvic inflammatory syndrome. Several broad-spectrum antibiotics are currently used to treat C. trachomatis. Although effective, they also kill beneficial vaginal lactobacilli.
Huirong Zhang, Anuj Kunadia, Yingfu Lin, Joseph D. Fondell, Daniel Seidel, Huizhou Fan   +5 more
openaire   +4 more sources

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Design, Synthesis, and Insecticidal Activity of Some Novel Diacylhydrazine and Acylhydrazone Derivatives

Molecules, 2015
In this study a series of diacylhydrazine and acylhydrazone derivatives were designed and synthesized according to the method of active group combination and the principles of aromatic group bioisosterism.
Jialong Sun, Yuanming Zhou
doaj   +1 more source

Polysaccharide-based fast self-healing ion gel based on acylhydrazone and metal coordination bonds

Materials & Design, 2020
The development of environmentally friendly and durable gel materials based on biomass is becoming critical today. In this paper, a kind of self-healing ion gel based on acylhydrazone bonds was firstly prepared by eco-friendly polysaccharide materials ...
Moshuqi Zhu, Hailun Jin, Tan Shao, Yuyu Li, Jian Liu, Lihui Gan, Minnan Long   +6 more
doaj   +1 more source

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Light‐Controlled Peptide Self‐Assembly: From Physicochemical Principles to Emerging Biomedical Applications

Aggregate, Volume 7, Issue 6, June 2026.
This review surveys recent advances in light‐controlled peptide self‐assembly for the design of smart soft matter. It summarizes the underlying physicochemical principles, including thermodynamic control for reshaping free‐energy landscapes, and nonequilibrium control to produce kinetically trapped states and dissipative structures.
Lidong Chen, Yanan Cui, Yuxuan Han, Chuqiang Ke, Wendi Jiang, Rui Yu, Lingling Kang, Kai Liu   +7 more
wiley   +1 more source

N′-[(E)-4-Methylbenzylidene]pyridine-4-carbohydrazide monohydrate

IUCrData, 2016
In the title hydrate, C14H13N3O·H2O, the C=N double bond adopts an E conformation and the dihedral angle between the aromatic rings is 16.36 (10)°. In the crystal, N—H...O, O—H...O and O—H...N hydrogen bonds link the components into (001) sheets.
Wanda Pereira Almeida, Isabela Paes Koury, Deborah de Alencar Simoni   +2 more
doaj   +1 more source

pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing

Materials & Design, 2021
The healing of diabetic foot ulcers (DFUs) is a major challenge for clinical treatment because of the hyperglycemic and acidic microenvironment in the wound area.
Zuhao Li, Yue Zhao, He Liu, Ming Ren, Zhonghan Wang, Xianggang Wang, Hou Liu, Yubin Feng, Quan Lin, Chenyu Wang, Jincheng Wang   +10 more
doaj   +1 more source