Results 71 to 80 of about 3,211 (225)

Stimuli‐Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Ring‐opening polymerization based on dynamic disulfide bond exchange is an important method for synthesizing poly(disulfide)s. These polymers possess stimulus‐responsive mechanisms and show broad prospects in intelligent drug delivery. This review systematically discusses the ring‐opening polymerization strategy and research progress of drug delivery ...
Yuechen He, Qiuhong Ouyang, Xinglv Chen, Qian Zhong, Xunhuan Song, Yujie Sun, Bingran Yu, Meng Qin   +7 more
wiley   +1 more source

A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

Molecules, 2019
In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles.
Anca-Maria Borcea, Gabriel Marc, Ioana Ionuț, Dan C. Vodnar, Laurian Vlase, Felicia Gligor, Andreea Pricopie, Adrian Pîrnău, Brîndușa Tiperciuc, Ovidiu Oniga   +9 more
doaj   +1 more source

Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles

ChemistryOpen, 2021
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura   +9 more
doaj   +1 more source

(E)-N'-(2, 4-dihydroxybenzylidene)nicotinohydrazide and its Metal Complexes: Synthesis, Characterisation and Antitubercular Activity [PDF]

, 2016
Nicotinic acid hydrazide and 2,4-dihydoxylbenzaldehyde were condensed at 20 °C to form an acylhydrazone (H3L1) with ONO coordination pattern. The structure of the acylhydrazone was elucidated by using CHN analyzer, ESI mass spectrometry, IR, 1H NMR, 13C ...
Adekoya, J. A.
core  

C-Glycosyl 1,2,4-triazoles: Synthesis of the 3-β-d-glucopyranosyl-1,5-disubstituted and 5-β-d-glucopyranosyl-1,3-disubstituted variants [PDF]

, 2017
K
Páhi, András, Somsák, László, Szabó, Erzsébet Katalin   +2 more
core   +1 more source

Investigation of Covalent Adaptable Networks (CANs) Based on Dynamic Acylhydrazone Bonds Featuring Shape‐Memory Ability

Journal of Applied Polymer Science, Volume 143, Issue 18, May 10, 2026.
Application of dynamic acylhydrazones to achieve CANs with shape‐memory properties. ABSTRACT Covalent adaptable networks (CANs) are based on reversible crosslinks, which are present within the polymer network structure. Due to these reversible moieties, CANs feature interesting properties/abilities such as self‐healing after damage, shape‐memory ...
Farhad Shohraty, Michael F. Agyemang, Michael Klein, Stefan Zechel, Michael Schmitt, Jürgen Popp, Martin D. Hager   +6 more
wiley   +1 more source

A pH-Responsive Drug Delivery System Based on Conjugated Polymer for Effective Synergistic Chemo-/Photodynamic Therapy

Molecules, 2023
Stimuli-responsive drug release and photodynamic therapy (PDT) have aroused extensive attention for their enormous potential in antitumor treatment. pH-responsive drug delivery systems (PFE-DOX-1 and PFE-DOX-2) based on water-soluble conjugated polymers ...
Chen Zhang, Qiong Yuan, Ziqi Zhang, Yanli Tang   +3 more
doaj   +1 more source

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes [PDF]

, 2013
Nucleos(t)ide analog therapy blocks DNA synthesis by the hepatitis B virus (HBV) reverse transcriptase and can control the infection, but treatment is life-long and has high costs and unpredictable long-term side effects.
A Agrawal, A Monto, Aleem Siddiqui, AM Woltman, B Werle-Lapostolle, C Chang, CA Shaw-Reid, CS Coffin, CW Shepard, D Ganem, D Lavanchy, DK Wong, DM Himmel, DM Himmel, E Michailidis, E. Jon Jacobsen, Eleftherios Michailidis, ER Goedken, F Cao, F Dyda, F Kurbanov, F van Bommel, F Zoulim, F Zoulim, F Zoulim, Feng Cao, G Radziwill, G Radziwill, G Woo, GJ Klarmann, GK Lau, GM Di, GR Foster, H Fuji, H Kwon, H Pelletier, H Wang, HP Su, HR Bokesch, J Beck, J Cheng, J Choi, J Didierjean, J Hu, J Hu, J Wu, J zu Putlitz, JE Tavis, JE Tavis, JJ Arnold, JJ Song, JL Keck, John E. Tavis, JS Tuttleman, JT Edward, K Katayanagi, K Klumpp, K Klumpp, K Takada, K Wursthorn, L Lin, LJ Chang, M Ariyoshi, M Billamboz, M Billamboz, M Buti, M Chen, M Ghany, M Levrero, M Nowotny, M Nowotny, M Ruggeri, M Sturmer, M Wendeler, M Wu, Marvin J. Meyers, MD Li, Michael A. Parniak, Michael Totten, ML Op den Brouw, MT Chen, N Cox, N Potenza, O Poch, P Frank, P Frank, P Marcellin, P Vanlandschoot, PA Rice, PD Williams, PN Cheng, Q Gong, Rajeev Aurora, RP Perrillo, S Chung, S Chung, SR Budihas, Stefan G. Sarafianos, T Gerelsaikhan, TA Kirschberg, V Suchaud, W Yang, WF Lima, WF Lima, X Wei, Xiaohong Cheng, Y Chen, Y Gong, Y Wei, Y Xu, YF Liaw, YI Lee, Yuan Hu   +112 more
core   +3 more sources

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Excimer Formation in Aqueous Solutions of Hosts and Application in Synthesis

ChemPhotoChem, Volume 10, Issue 4, April 2026.
This review explores how host‐mediated excimer formation in water, facilitated by supramolecular confinement enhances photochemical synthesis. By improving solubility, local concentrations, and orientational control, these systems can boost efficiency and selectivity in reactions like photocycloadditions and photodimerizations.
Doğan Akbulut, Florian Friedmann, Gianna Pölderl, Line Næsborg   +3 more
wiley   +1 more source