Results 81 to 90 of about 3,211 (225)

Synthesis and structure of (E)-3,4,5-trihydroxy-N′-(3,4,5-trimethoxybenzylidene)benzohydrazide monohydrate

Acta Crystallographica Section E: Crystallographic Communications
In the structure of the title compound, C17H18N2O7·H2O, hydrogen bonds link three molecules to the water molecule. Additional hydrogen-bonding interactions connect two molecules via the amide nitrogen donor and two methoxy oxygen acceptors.
Mamadou Lo, Bineta Sene, Adji Fatou Fall Pouye, Arie van der Lee, Abdoulaye Gassama, Sébastien Richeter   +5 more
doaj   +1 more source

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Organic Letters, 2020
Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion ...
Yuntao Zhou, Irene Piergentili, Jennifer Hong, Michelle P. van der Helm, Mariano Macchione, Yao Li, Rienk Eelkema, Sanzhong Luo   +7 more
openaire   +4 more sources

Toward Model Amphiphilic Polymer Co‐Networks: Linking Architecture to Structure and Properties

Macromolecular Chemistry and Physics, Volume 227, Issue 7, 14 April 2026.
This review provides a comprehensive overview on model amphiphilic polymer co‐networks, demonstrating how precise control over network architecture enables systematic investigation of their structure and properties. By linking molecular design to macroscopic behavior, it highlights fundamental structure–property relationships and shows how these ...
Sebastian Seitel, David Beyer, Frank Böhme, Carolin Bunk, Yasmina El‐Faramawi, Jonas J. Grün, Kevin Hagmann, Christian Holm, Michael Lang, Kay Saalwächter, Felix H. Schacher, Reinhard Scholz, Regine von Klitzing, Marie Weinhart, Sebastian Seiffert   +14 more
wiley   +1 more source

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Molecules, 2020
In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties.
Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, Aleksandra Misicka   +5 more
doaj   +1 more source

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors [PDF]

, 2014
Plasmodium parasites, the causative agents of malaria, have developed resistance to most of our current antimalarial therapies, including artemisinin combination therapies which are widely described as our last line of defense. Antimalarial agents with a
Abdel-Magid A. F., Adams P. D., Afonine P. V., Alessandro Paiardini, Androulakis S., Babine R. E., Battye T. G., Biffis A., Bramucci E., Brunger A. T., Carroll R. K., CCP4., Changklungmoa N., Chiara Ruggeri, Chouhan G., Chowdhury N., Correa A., Cristau H. J., Deprez-Poulain R., Didier E. S., Dong L., Duffy S., Eswar N., Evans P., Evans P. R., Flipo M., Flipo M., Flipo M., Freedman L. D., Harbut M. B., Hitzerd S. M., Huang Q., Joseph P., Kabsch W., Kannan Sivaraman K., Klemba M., Komagal Kannan Sivaraman, Lee J., Lew V. L., Li F., Li L., Liguori A., Liu J., Marcin Drag, Massaro A., McGowan S., McGowan S., McGowan S., Meyer G. R., Mucha A., Nyssa Drinkwater, Oshovsky G. V., Peter J. Scammells, Poreba M., Riva E., Rosenthal P. J., Sabine Fletcher, Sang Q., Sasdekumar Loganathan, Schüttelkopf A. W., Shailesh N. Mistry, Sheena McGowan, Sivaraman K. K., Skinner-Adams T. S., Sreedhar B., Stack C. M., Swapna K., Taillefer M., Thomsen R., Tubaro C., Tufariello J. J., Uk Son S., Usachova N., Velmourougane G., Vicky M. Avery, Wadhwa K., Wickstrom M., Xu Z.-L., Zmitek J., Zou B.   +79 more
core   +4 more sources

On‐Demand Chemically Degradable Hydrogels for Biological Applications

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
This review explores the mechanisms and kinetics of chemically induced on‐demand degradation in hydrogels designed for painless dressing removal and traceless dissolution across various biological applications. Covalent bond cleavage and noncovalent disruption triggers are compared, highlighting opportunities for load‐bearing scaffolds with faster ...
Xinyi Sheng, Justin Kim
wiley   +1 more source

Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats

Microbiology Spectrum
Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of sporotrichosis.
Isabella Dib Ferreira Gremião, Gabriela Reis Pereira-Oliveira, Sandro Antonio Pereira, Maria Lopes Corrêa, Luana Pereira Borba-Santos, Alessandra Lifsitch Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel S. Matos, Vanessa Silva, Cristina Lazzarini, Caroline Mota Fernandes, Kildare Miranda, Jhon Jhamilton Artunduaga Bonilla, Anna Letícia Nunes, Leonardo Nimrichter, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta   +21 more
doaj   +1 more source

Color-tunable single-fluorophore supramolecular system with assembly-encoded emission

Nature Communications, 2020
Regulating fluorescent properties of small molecules in a controlled manner has been a fundamental research goal but realizing multi-color emission from a single fluorophore remains challenging.
Qian Wang, Qi Zhang, Qi-Wei Zhang, Xin Li, Cai-Xin Zhao, Tian-Yi Xu, Da-Hui Qu, He Tian   +7 more
doaj   +1 more source

Ribonuclease H/DNA polymerase HIV-1 reverse transcriptase dual inhibitor: mechanistic studies on the allosteric mode of action of isatin-based compound RMNC6 [PDF]

, 2016
The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome and are validated drug targets.
Alcaro, S, Bianco, G, Corona, A, Distinto, S, Esposito, F, Le Grice, SFJ, Maccioni, E, Masaoka, T, Meleddu, R, Menéndez-Arias, L, Tramontano, E   +10 more
core   +5 more sources

Discovery of Inhibitors by Combinatorial-Chemistry Approaches [PDF]

, 2020
This thesis describes our efforts to develop inhibitors using combinatorial-chemistry approaches. These approaches can potentially speed-up the drug discovery trajectory and the discovered molecules could be used as starting points for future drug ...
van der Vlag, Ramon
core   +2 more sources