Results 41 to 50 of about 2,678 (221)
N′-[1-(Pyrazin-2-yl)ethylidene]pyrazine-2-carbohydrazide
IUCrData, 2018 The title compoud, C11H10N6O, was synthesized by the condensation reaction of pyrazine-2-carbohydrazide with 2-acetylpyrazine in ethanol. The dihedral angle between the pyrazine rings is 4.7 (3)°.
Zhaodong Wang
doaj +1 more source
Oral Antithrombotic Effects of Acylhydrazone Derivatives
Journal of Atherosclerosis and Thrombosis, 2013 In the search for new antithrombotic drug candidates, the synthesis and anti-platelet activity of a new series of N-acylhydrazones that were designed as thrombin inhibitors has been previously described. The aim of this work was to further characterize the effects of these compounds on thrombin-induced platelet aggregation and induced thrombosis in ...
Frattani, Flávia Serra +4 more
openaire +3 more sources
Global Challenges, 2019 Gel adsorbents are promising for pollutant removal from the wastewater. Herein, an acylhydrazone gel is developed from acylhydrazide‐terminated pentaerythritol (PAT) and 2,4,6‐triformylphloroglucinol (TFP) based on dynamic covalent acylhydrazone ...
Haobin Fang +4 more
doaj +1 more source
Design, Synthesis, Antinociceptive and Anti-Inflammatory Activities of Novel Piroxicam Analogues
Molecules, 2012 In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug ...
Eliezer J. Barreiro +8 more
doaj +1 more source
Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties. [PDF]
PLoS ONE, 2016 LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme, which participates in the activation of the nuclear factor κB (NF-κB) canonical pathway, and its three N-acylhydrazone new analogues, LASSBio-1760, LASSBio-1763 and ...
Natália M Cordeiro +3 more
doaj +1 more source
(5-Hydroxy-3-methyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl)(2-hydroxyphenyl)methanone
IUCrData, 2016 In the title compound, C12H11F3N2O3, the hydroxyphenyl ring is twisted by 35.42 (11)° from the plane of the pyrazoline ring. The keto O atom is involved in two intramolecular O—H...O hydrogen bonds, which generate S(6) loops.
Kuvondik G. Avezov +4 more
doaj +1 more source
Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications [PDF]
Royal Society Open Science, 2017 As one of common dynamic covalent bonds, acylhydrazone bond plays an important role in developing intelligent responsive materials. In this report, we present acylhydrazone-based dynamic polymers with multi-stimuli responsiveness, particularly metal ...
Siheng Gao +4 more
doaj +1 more source
Macromol, 2021 Acylhydrazone-based fluorescent conjugated microporous polymers (CMPs) with inter-and intra-hydrogen bonding-controlled emissive properties were prepared.
Inhwan Cha +7 more
doaj +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Molecules, 2018 During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at specific positions on BT scaffold modulate the antitumor property. The potential of BTs encouraged us to synthesize a number of new 2-((
Derya Osmaniye +5 more
openaire +4 more sources