Results 41 to 50 of about 1,339 (180)

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials

Journal of Periodontal Research, EarlyView.
Hydrogel‐based therapies have proven to be valuable tools to address the unique regeneration challenges of complex multi‐domain periodontal and craniofacial tissues. This review highlights and classifies clinically approved and emerging hydrogel therapies indicated for the regeneration of periodontal and craniofacial tissues.
Z. Gouveia, M. Diba, B. T. Yilmaz, Jae‐Kook Cha, D. T. Wu, D. J. Mooney   +5 more
wiley   +1 more source

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents

Molecules, 2018
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at specific positions on BT scaffold modulate the antitumor property. The potential of BTs encouraged us to synthesize a number of new 2-((
Derya Osmaniye, Serkan Levent, Abdullah Burak Karaduman, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı   +5 more
openaire   +4 more sources

N′-[(E)-4-Methylbenzylidene]pyridine-4-carbohydrazide monohydrate

IUCrData, 2016
In the title hydrate, C14H13N3O·H2O, the C=N double bond adopts an E conformation and the dihedral angle between the aromatic rings is 16.36 (10)°. In the crystal, N—H...O, O—H...O and O—H...N hydrogen bonds link the components into (001) sheets.
Wanda Pereira Almeida, Isabela Paes Koury, Deborah de Alencar Simoni   +2 more
doaj   +1 more source

A new series of acylhydrazones derived from metribuzin with modulated herbicidal activity

Heliyon, 2023
This paper reports the preparation and herbicidal evaluation of a small library of acylhydrazones based on the synthetic herbicide metribuzin. The hydrazone linkage easily obtained by reaction of metribuzin with aliphatic and aromatic aldehydes, masks ...
David Peña, Antonio López-Piñeiro, Damian Fernández, Mark E. Light, Juan Manuel Prieto, Lucía Santisteban, Richardo Xhavier Valladares, Pedro Cintas, Reyes Babiano   +8 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Identification of a strong and specific antichlamydial N-acylhydrazone

PLOS ONE, 2017
Sexually transmitted Chlamydia trachomatis is an extremely common infection and often leads to serious complications including infertility and pelvic inflammatory syndrome. Several broad-spectrum antibiotics are currently used to treat C. trachomatis. Although effective, they also kill beneficial vaginal lactobacilli.
Huirong Zhang, Anuj Kunadia, Yingfu Lin, Joseph D. Fondell, Daniel Seidel, Huizhou Fan   +5 more
openaire   +4 more sources

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

Molecules, 2019
In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles.
Anca-Maria Borcea, Gabriel Marc, Ioana Ionuț, Dan C. Vodnar, Laurian Vlase, Felicia Gligor, Andreea Pricopie, Adrian Pîrnău, Brîndușa Tiperciuc, Ovidiu Oniga   +9 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, Volume 13, Issue 46, 17 August 2026.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles

ChemistryOpen, 2021
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura   +9 more
doaj   +1 more source