Results 41 to 50 of about 3,211 (225)
Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties. [PDF]
PLoS ONE, 2016 LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme, which participates in the activation of the nuclear factor κB (NF-κB) canonical pathway, and its three N-acylhydrazone new analogues, LASSBio-1760, LASSBio-1763 and ...
Natália M Cordeiro +3 more
doaj +1 more source
Current and future chemotherapy for Chagas disease [PDF]
, 2015 Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela +10 more
core +1 more source
(5-Hydroxy-3-methyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl)(2-hydroxyphenyl)methanone
IUCrData, 2016 In the title compound, C12H11F3N2O3, the hydroxyphenyl ring is twisted by 35.42 (11)° from the plane of the pyrazoline ring. The keto O atom is involved in two intramolecular O—H...O hydrogen bonds, which generate S(6) loops.
Kuvondik G. Avezov +4 more
doaj +1 more source
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry [PDF]
, 2013 Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other.
Li, Jianwei, +2 more
core +3 more sources
Differential metal-binding properties of dynamic acylhydrazone polymers and their sensing applications [PDF]
Royal Society Open Science, 2017 As one of common dynamic covalent bonds, acylhydrazone bond plays an important role in developing intelligent responsive materials. In this report, we present acylhydrazone-based dynamic polymers with multi-stimuli responsiveness, particularly metal ...
Siheng Gao +4 more
doaj +1 more source
Macromol, 2021 Acylhydrazone-based fluorescent conjugated microporous polymers (CMPs) with inter-and intra-hydrogen bonding-controlled emissive properties were prepared.
Inhwan Cha +7 more
doaj +1 more source
Smart systems related to polypeptide sequences [PDF]
, 2016 Increasing interest for the application of polypeptide-based smart systems in the biomedical field has developed due to the advantages given by the peptidic sequence.
Franco García, María Lourdes +2 more
core +2 more sources
Mastering tricyclic ring systems for desirable functional cannabinoid activity [PDF]
, 2013 There is growing interest in using cannabinoid receptor 2 (CB2) agonists for the treatment of neuropathic pain and other indications. In continuation of our ongoing program aiming for the development of new small molecule cannabinoid ligands, we have ...
Barth, Francis +10 more
core +2 more sources
Advanced Functional Materials, EarlyView.A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao +6 more
wiley +1 more source
Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives
BMC Chemistry, 2022 N-acylhydrazones are considered privileged structures in medicinal chemistry, being part of antimicrobial compounds (for example). In this study we show the activity of N-acylhydrazone compounds, namely AH1, AH2, AH4, AH5 in in vitro tests against the ...
Fernanda A. Oliveira +8 more
doaj +1 more source