Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives [PDF]
BMC Chemistry, 2022 N-acylhydrazones are considered privileged structures in medicinal chemistry, being part of antimicrobial compounds (for example). In this study we show the activity of N-acylhydrazone compounds, namely AH1, AH2, AH4, AH5 in in vitro tests against the ...
Fernanda A. Oliveira +8 more
doaj +4 more sources
Design, synthesis and antifungal activity of novel 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety [PDF]
Frontiers in Chemistry, 2023 A series of 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro antifungal activities against Gibberella zeae, Pellicularia sasakii, Phytophthora infestans, Capsicum wilt, and ...
Chenghao Tang +5 more
doaj +2 more sources
Design, Synthesis, and Bioactivity Study of Novel Tryptophan Derivatives Containing Azepine and Acylhydrazone Moieties [PDF]
Molecules, 2022 Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing azepine and acylhydrazone moieties have been designed, synthesized, characterized, and evaluated for their biological activities.
Jingjing Zhang +6 more
doaj +2 more sources
Acylhydrazones and Their Biological Activity: A Review
Molecules, 2022 Due to the structure of acylhydrazones both by the pharmacophore –CO–NH–N= group and by the different substituents present in the molecules of compounds of this class, various pharmacological activities were reported, including antitumor, antimicrobial ...
Laura-Ileana Socea +6 more
doaj +3 more sources
Discovery of Bacillamide–Acylhydrazone Hybrids as Novel Fungicide Lead Compounds [PDF]
Journal of FungiTo identify fungicide lead compounds with novel scaffolds and high efficacy, 33 novel bacillamide–acylhydrazone derivatives were successfully designed and synthesized by using a molecular hybridization strategy.
Sijia Feng +4 more
doaj +2 more sources
Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues
Molecules, 2023 Compounds with acylhydrazone fragments contain amide and imine groups that can act as electron donors and acceptors, so they are easier to bind to biological targets and thus generally exhibit significant biological activity.
Hongjian Song +2 more
exaly +3 more sources
Exploring Acylhydrazones’ Properties Against Neurodegenerative Diseases and Other Clinical Applications: A Review [PDF]
PharmaceuticalsNeurodegenerative diseases are a serious problem for modern society, and their treatment remains an important issue discussed by the scientific community.
Julia Skroban +2 more
doaj +2 more sources
Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates [PDF]
MoleculesIn our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone β-carboline analogues 9a–o and 10a–o for their effectiveness against Valsa mali, Fusarium solani, Fusarium oxysporum, and ...
Yujie Xu +5 more
doaj +2 more sources
Computational Study of Linker Polarity Effects on Optical Electron Transfer in Imine- and Acylhydrazone-Linked Covalent Organic Frameworks Using Fragment Models. [PDF]
MoleculesChen J, Qi D, Jiang J.
europepmc +3 more sources
Square-planar and octahedral nickel complexes of an acylhydrazone ligand and the serendipitous isolation of a potential octahedral nickel acylhydrazone precursor [PDF]
CrystEngComm, 2023 An investigation of the coordination chemistry of the ((E)-N′-(4-hydroxybenzylidene)-4-hydroxybenzohydrazide) Schiff-based ligand (HL) towards Ni(ii) acetate was performed using single crystal X-ray diffraction.
Rosa Carballo +4 more
openalex +3 more sources