Results 11 to 20 of about 3,211 (225)

Design, Synthesis, and Antifungal Activity of Some Novel Phenylthiazole Derivatives Containing an Acylhydrazone Moiety

Molecules, 2023
Crop fungal diseases pose a serious threat to global crop production and quality. Developing new and efficient fungicides is an important measure to control crop diseases.
Yao Tian, Jinchao Shi, Xiaoqian Deng, Tingyu Yu, Yong Hu, Richa Hu, Yufeng Lei, Linhua Yu, Xiang Zhu, Junkai Li   +9 more
doaj   +1 more source

Assignments of NMR Spectral Data of a Novel Carbazole-Triazinoindole Based N-Acylhydrazone Derivative

Chinese Journal of Magnetic Resonance, 2020
N-acylhydrazone compounds have two isomers, E/cis and E/trans, in polar solvents. In this work, 1H and 13C nuclear magnetic resonance (NMR) signals, coupling constants (J), and the spatial structures of the two isomers (E/cis and E/trans) of a novel ...
LI Ying-jun, YANG Hong-jing, LIU Ji-hong, JIN Kun, LIN Le-di, LIU Xue-jie   +5 more
doaj   +1 more source

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Molecules, 2021
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory and ...
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro   +8 more
doaj   +1 more source

Design, Synthesis, and Bioactivities of Novel Tryptophan Derivatives Containing 2,5-Diketopiperazine and Acyl Hydrazine Moieties

Molecules, 2022
Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing 2,5-diketopiperazine and acyl hydrazine moieties have been designed, synthesized, characterized, and evaluated for their biological activities.
Lili Li, Rongxin Yang, Jianhua Liu, Jingjing Zhang, Hongjian Song, Yuxiu Liu, Qingmin Wang   +6 more
doaj   +1 more source

Design, synthesis and antifungal activity of novel 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety

Frontiers in Chemistry, 2023
A series of 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro antifungal activities against Gibberella zeae, Pellicularia sasakii, Phytophthora infestans, Capsicum wilt, and ...
Chenghao Tang, Wenbo Guo, Shengzhou Yang, Xiuhong Hu, Xingju Chen, Xiang Wang   +5 more
doaj   +1 more source

Chelation motifs affecting metal-dependent viral enzymes: N′-acylhydrazone ligands as dual target inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H domain [PDF]

, 2017
Human immunodeficiency virus type 1 (HIV-1) infection, still represent a serious global health emergency. The chronic toxicity derived from the current anti-retroviral therapy limits the prolonged use of several antiretroviral agents, continuously ...
Carcelli, Mauro, Caredda, Alessia, Corona, Angela, Esposito, Francesca, Gatti, Anna, Naesens, Lieve, Pala, Nicolino, Pannecouque, Christophe, Rogolino, Dominga, Tramontano, Enzo   +9 more
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Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry [PDF]

, 2012
A bivalent dynamic covalent chemistry (DCC) system has been designed to selectively target members of the homodimeric glutathione-S-transferase (GST) enzyme family.
Ang, Appiah-Opong, Beeren, Beeren, Beeren, Bhat, Bhat, Blanden, Bunyapaiboonsri, Bunyapaiboonsri, Carroll, Cheng, Cho, Corbett, Corbett, Corbett, Cordes, Cousins, Deng, Dirksen, Dorion, Erlanson, Federici, Furlan, Gromova, Habig, Hayes, Hochgürtel, Huc, Jao, Li, Lins, Liu, Liénard, Liénard, Lyon, Maeda, Mahajan, Mannervik, McIlwain, Oakley, Oakley, Oakley, Patskovsky, Poulsen, Poulsen, Ralat, Ramström, Ramström, Roberts, Romieu, Ryoo, Sampsonas, Severin, Sheehan, Shi, Simpson, Simpson, Son, Townsend, Tsuboi, Woon, Xue, Zameo, Zameo   +64 more
core   +1 more source

Design, Synthesis, and Bioactivity Evaluation of Novel Isoxazole-Amide Derivatives Containing an Acylhydrazone Moiety as New Active Antiviral Agents

Molecules, 2019
As a continuation of our efforts to discover and develop “me-better” active molecules, in this study, a series of novel isoxazole-amide derivatives containing an acylhydrazone moiety were synthesized and evaluated for their antiviral ...
Zai-Bo Yang, Pei Li, Yin-Ju He
doaj   +1 more source

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues

Molecules, 2023
Compounds with acylhydrazone fragments contain amide and imine groups that can act as electron donors and acceptors, so they are easier to bind to biological targets and thus generally exhibit significant biological activity.
Wanjun Ni, Hongjian Song, Lizhong Wang, Yuxiu Liu, Qingmin Wang   +4 more
doaj   +1 more source

Effect of the polymer structure on the viscoelastic and interfacial healing behaviour of poly(urea-urethane) networks containing aromatic disulphides [PDF]

, 2017
The macroscopic interfacial healing behaviour in a series of urea-urethane networks as function of the hydrogen bonds and disulphides content is presented.
Garcia, S. J., Grande, ANTONIO MATTIA, Martin, R., Odriozola, I., Van Der Zwaag, S.   +4 more
core   +1 more source