Results 11 to 20 of about 1,339 (180)

Synthesis and Biological Activities of C1-Substituted Acylhydrazone β-Carboline Analogues as Antifungal Candidates [PDF]

Molecules
In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone β-carboline analogues 9a–o and 10a–o for their effectiveness against Valsa mali, Fusarium solani, Fusarium oxysporum, and ...
Yujie Xu, Lishan Li, Jinghan Zhang, Yu Lan, Na Li, Junru Wang   +5 more
doaj   +2 more sources

Discovery of Bacillamide–Acylhydrazone Hybrids as Novel Fungicide Lead Compounds [PDF]

Journal of Fungi
To identify fungicide lead compounds with novel scaffolds and high efficacy, 33 novel bacillamide–acylhydrazone derivatives were successfully designed and synthesized by using a molecular hybridization strategy.
Sijia Feng, Yuxiao Zhang, Peipei Shi, Ke Chen, Kang Lei   +4 more
doaj   +2 more sources

Exploring Acylhydrazones’ Properties Against Neurodegenerative Diseases and Other Clinical Applications: A Review [PDF]

Pharmaceuticals
Neurodegenerative diseases are a serious problem for modern society, and their treatment remains an important issue discussed by the scientific community.
Julia Skroban, Marta Kruk-Słomka, Łukasz Popiołek   +2 more
doaj   +2 more sources

Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514

Molecules, 2021
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory and ...
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro   +8 more
doaj   +1 more source

Design, Synthesis, and Bioactivities of Novel Tryptophan Derivatives Containing 2,5-Diketopiperazine and Acyl Hydrazine Moieties

Molecules, 2022
Based on the scaffolds widely used in drug design, a series of novel tryptophan derivatives containing 2,5-diketopiperazine and acyl hydrazine moieties have been designed, synthesized, characterized, and evaluated for their biological activities.
Lili Li, Rongxin Yang, Jianhua Liu, Jingjing Zhang, Hongjian Song, Yuxiu Liu, Qingmin Wang   +6 more
doaj   +1 more source

Design, synthesis and antifungal activity of novel 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety

Frontiers in Chemistry, 2023
A series of 1,4-benzoxazin-3-one derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro antifungal activities against Gibberella zeae, Pellicularia sasakii, Phytophthora infestans, Capsicum wilt, and ...
Chenghao Tang, Wenbo Guo, Shengzhou Yang, Xiuhong Hu, Xingju Chen, Xiang Wang   +5 more
doaj   +1 more source

3-Aminothiophene-2-Acylhydrazones: Non-Toxic, Analgesic and Anti-Inflammatory Lead-Candidates

Molecules, 2014
Different chemotypes are described as anti-inflammatory. Among them the N-acylhydrazones (NAH) are highlighted by their privileged structure nature, being present in several anti-inflammatory drug-candidates.
Yolanda Karla Cupertino da Silva, Christian Tadeo Moreno Reyes, Gildardo Rivera, Marina Amaral Alves, Eliezer J. Barreiro, Magna Suzana Alexandre Moreira, Lídia Moreira Lima   +6 more
doaj   +1 more source

New Palladacycle-Derived Acylhydrazones as Pre-catalysts in Mirozoki-Heck Coupling and Oxyarylations

Anais da Academia Brasileira de Ciências, 2018
New acylhydrazone-based palladacycles are prepared and evaluated as pre-catalysts in Mirozoki-Heck and oxyarylation reactions.
RAQUEL A.C. LEÃO, VAGNER D. PINHO, ARTUR S. COELHO, ARTHUR E. KÜMMERLE, PAULO R.R. COSTA   +4 more
doaj   +1 more source

Acylhydrazones as Widely Tunable Photoswitches

Journal of the American Chemical Society, 2015
Molecular photoswitches have attracted much attention in biological and materials contexts. Despite the fact that existing classes of these highly interesting functional molecules have been heavily investigated and optimized, distinct obstacles and inherent limitations remain.
Derk Jan van Dijken, † Petr Kovaříček, ‡ Svante P. Ihrig, and Stefan Hecht*   +3 more
openaire   +3 more sources

Construction of diazepine-containing spiroindolines via annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates

Beilstein Journal of Organic Chemistry, 2023
A straightforward synthetic protocol for the efficient construction of diazepine-containing spiroindolines has been developed and proceeds through a by base-promoted annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates.
Xing Liu, Wenjing Shi, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source