Results 1 to 10 of about 1,401,210 (353)

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

Physiological Reports, 2020
Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury.
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh   +7 more
doaj   +1 more source

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

Physiological Reports, 2020
Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of immune cells ...
Edgars Liepinsh, Elina Makarova, Liga Plakane, Ilze Konrade, Kaspars Liepins, Melita Videja, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka‐Kuka, Maija Dambrova   +9 more
doaj   +1 more source

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Neurobiology of Disease, 2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and ...
Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Svalbe, Karlis Vilks, Einars Kupats, Rudolfs Mezapuke, Lasma Lauberte, Maija Dambrova, Liga Zvejniece   +9 more
doaj   +1 more source

Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition

Scientific Reports, 2023
Fructosyl peptide oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and ...
Hajar Estiri, Shapla Bhattacharya, Jhon Alexander Rodriguez Buitrago, Rossella Castagna, Linda Legzdiņa, Giorgia Casucci, Andrea Ricci, Emilio Parisini, Alfonso Gautieri   +8 more
doaj   +1 more source

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

Molecules, 2023
Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes.
Anna Nikitjuka, Kristaps Krims-Davis, Iveta Kaņepe-Lapsa, Melita Ozola, Raivis Žalubovskis   +4 more
doaj   +1 more source

Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones [PDF]

, 2007
The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route.
Clarke, Paul A., Martin, William H. C., Santos, Soraia   +2 more
core   +1 more source

Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

Chimica Techno Acta, 2022
The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-
Dmitry S. Kopchuk, Alexey P. Krinochkin, Мaria I. Valieva, Еkaterina S. Starnovskaya, Yaroslav K. Shtaitz, Svetlana S. Rybakova, Evgeny D. Ladin, Ekaterina A. Kudryashova, Elvira R. Sharafieva, Оleg N. Chupakhin   +9 more
doaj   +1 more source

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide

Molbank, 2022
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromination
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins   +7 more
doaj   +1 more source

Early stages of phase selection in MOF formation observed in molecular Monte Carlo simulations [PDF]

, 2019
Metal-organic frameworks (MOF) comprising metal nodes bridged by organic linkers show great promise because of their guest-specific gas sorption, separation, drug-delivery, and catalytic properties.
Cessford, Naomi F., Düren, Tina, Seaton, Nigel A., Wells, Stephen A.   +3 more
core   +1 more source

Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation

Czech Journal of Food Sciences, 2001
Antioxidants with 1,4-dihydropyridine structure were investigated as a less harmful alternative to synthetic phenolic antioxidants in liposomes under conditions simulating food storage.
G. Tirzitis, D. Tirzite, Z. Hyvonen
doaj   +1 more source