Results 21 to 30 of about 4,566,280 (295)

Electrifying Organic Synthesis [PDF]

Angewandte Chemie International Edition, 2018
AbstractThe direct synthetic organic use of electricity is currently experiencing a renaissance. More synthetically oriented laboratories working in this area are exploiting both novel and more traditional concepts, paving the way to broader applications of this niche technology.
Anton Wiebe, Tile Gieshoff, Sabine Möhle, Eduardo Rodrigo, Michael Zirbes, Siegfried R. Waldvogel   +5 more
openaire   +2 more sources

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

Scientific Reports, 2020
The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts.
Marina Makrecka-Kuka, Pavels Dimitrijevs, Ilona Domracheva, Kristaps Jaudzems, Maija Dambrova, Pavel Arsenyan   +5 more
doaj   +1 more source

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

Physiological Reports, 2020
Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury.
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh   +7 more
doaj   +1 more source

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

Physiological Reports, 2020
Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of immune cells ...
Edgars Liepinsh, Elina Makarova, Liga Plakane, Ilze Konrade, Kaspars Liepins, Melita Videja, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka‐Kuka, Maija Dambrova   +9 more
doaj   +1 more source

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Neurobiology of Disease, 2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and ...
Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Svalbe, Karlis Vilks, Einars Kupats, Rudolfs Mezapuke, Lasma Lauberte, Maija Dambrova, Liga Zvejniece   +9 more
doaj   +1 more source

Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition

Scientific Reports, 2023
Fructosyl peptide oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and ...
Hajar Estiri, Shapla Bhattacharya, Jhon Alexander Rodriguez Buitrago, Rossella Castagna, Linda Legzdiņa, Giorgia Casucci, Andrea Ricci, Emilio Parisini, Alfonso Gautieri   +8 more
doaj   +1 more source

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

Molecules, 2023
Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes.
Anna Nikitjuka, Kristaps Krims-Davis, Iveta Kaņepe-Lapsa, Melita Ozola, Raivis Žalubovskis   +4 more
doaj   +1 more source

Dendritic supports in organic synthesis [PDF]

Reviews in Molecular Biotechnology, 2002
An overview is presented of the recent developments in the use of dendritic supports in organic synthesis. Examples are presented of the application of dendritic supports in both liquid- and solid-phase organic synthesis. In liquid-phase synthesis, soluble dendrimers are used as the substrate support, while in solid-phase synthesis, 'dendronized ...
Klein Gebbink, R.J.M., Kruithof, C.A., van Klink, G.P.M., van Koten, G.   +3 more
openaire   +4 more sources

Photobiocatalytic Strategies for Organic Synthesis

Chemical Reviews, 2023
Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions involve molecules operating from their ground states. Over the past 25 years, there has been an increased interest in enzymatic processes that utilize electronically excited ...
Emmanuel, Megan A., Bender, Sophie G., Bilodeau, Catherine, Carceller, Jose M., DeHovitz, Jacob S., Fu, Haigen, Liu, Yi, Nicholls, Bryce T., Ouyang, Yao, Page, Claire G., Qiao, Tianzhang, Raps, Felix C., Sorigué, Damien R., Sun, Shang-Zheng, Turek-Herman, Joshua, Ye, Yuxuan, Rivas-Souchet, Ariadna, Cao, Jingzhe, Hyster, Todd K.   +18 more
openaire   +4 more sources

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide

Molbank, 2022
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromination
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins   +7 more
doaj   +1 more source