Results 121 to 130 of about 1,401,210 (353)

Antituberculosis activity of some 3,6-disubstituted 1,2,4,5-tetrazines

Chimica Techno Acta
The increase in the incidence of tuberculosis, especially in the post-Covid period, associated with the presence of latent infections and multiple drug resistance, dictates the need to develop new antimicrobial drugs. Here we wish to report the synthesis
Rashida I. Ishmetova, Ilya N. Ganebnykh, Nina K. Ignatenko, Irina G. Ovchinnikova, Olga V. Fedorova, Sergei N. Skornyakov, Gennady L. Rusinov   +6 more
doaj   +1 more source

Lithiation of 4-membered heterocycles as useful strategy for the preparation of new molecular scaffolds: addressing the regioselectivity in azetidines and thietanes [PDF]

, 2013
Four-membered heterocycles (4-MH) with one or two heteroatoms are of great importance in medicinal chemistry and synthetic organic chemistry. This kind of scaffolds show peculiar structural features, related to the ring “puckering”, and biological ...
Carroccia, Laura, Degennaro, Leonardo, Falcicchio, Aurelia, Giovine, Arianna, Luisi, Renzo, Pisano, Luisa, Trinchera, Piera, Zenzola, Marina   +7 more
core  

A Spitzer/IRS spectral study of a sample of galactic carbon-rich proto-planetary nebulae

, 2010
Recent infrared spectroscopic observations have shown that proto-planetary nebulae (PPNs) are sites of active synthesis of organic compounds in the late stages of stellar evolution.
Bernard-Salas, Bernard-Salas, Bruce J. Hrivnak, Cerrigone, Henry, Houck, Hrivnak, Hrivnak, Hu, Hudgins, Jones, Keller, Kelly, Kwok, Kwok, Kwok, Kwok, Meixner, Nakashima, Pendleton, Posch, Pottasch, Rosenthal, Scott, Sloan, Sloan, Smith, Speck, Sun Kwok, Suzuki, Van Kerckhoven, Volk, Volk, Volk, Werner, Yong Zhang, Zhang   +36 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Hydrothermal Organic Synthesis Experiments [PDF]

, 1992
The serious scientific debate about spontaneous generation which raged for centuries reached a climax in the nineteenth century with the work of Spallanzani, Schwann, Tyndall, and Pasteur. These investigators demonstrated that spontaneous generation from dead organic matter does not occur (see reviews by Conant, 1953 and Kenyon and Steinman, 1969 ...
openaire   +2 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Growth and reductive transformation of a gold shell around pyramidal cadmium selenide nanocrystals

, 2010
We report the growth of an unstable shell-like gold structure around dihexagonal pyramidal CdSe nanocrystals in organic solution and the structural transformation to spherical domains by two means: i) electron beam irradiation (in situ) and (ii) addition
Andreas Kornowski, Beatriz H. Juárez, Burda, Carbone, Choi, Christian Klinke, Costi, Cozzoli, Daniel, Deka, Figuerola, Gu, He, Horst Weller, Huang, Jana, Juárez, Juárez, Kim, Liz-Marzán, Liz-Marzán, Lu, Michaela Meyns, Mokari, Mokari, Murray, Neus G. Bastus, Pacholski, Pellegrino, Rodríguez-Fernández, Sau, Wetz, Yang, Yuxue Cai, Zeng, Zheng   +35 more
core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Development of Mitochondria-Targeted PARP Inhibitors

Biomolecules
PARP inhibitors are a clinically validated class of anticancer therapeutics that exploit synthetic lethality to target homologous recombination-deficient tumors, such as those carrying BRCA1/2 mutations.
Pavels Dimitrijevs, Marina Makrecka-Kuka, Pavel Arsenyan   +2 more
doaj   +1 more source

Improved preparation of 9-octadecenes [PDF]

Organic synthesis of cis-9 and trans-9 octadecenes from oleyl alcohol and elaidyl alcohol, respectively, by conversion to tosylates followed by lithium aluminum hydride ...
Dyen, M. E., Hamann, H. C., Swern, D.
core   +1 more source