Results 31 to 40 of about 1,401,210 (353)

Straightforward Synthesis of α,β-Unsaturated Thioesters via Ruthenium-Catalyzed Olefin Cross-Metathesis with Thioacrylate [PDF]

, 2008
The cross-metathesis reaction of S-ethyl thioacrylate with a variety of olefins is effectively catalyzed by using a ruthenium benzylidene olefin metathesis catalyst.
Feringa, Ben L.,, Minnaard, Adriaan J.,, Zijl, Anthoni W. van,   +2 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Approaches to the Total Synthesis of Conduramines: A Review

SynOpen, 2022
This review reports on the total synthesis of conduramines, which are formally derived from conduritols, mainly containing a trihydroxy aminocyclohexene core.
Hanumantharayappa Bharathkumar, Jattuboyina Siva Krishna, Banothu Surender, Venkateswara Rao Batchu   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis

Communications Chemistry
Serine proteases in ribosomally synthesized and post-translationally modified peptides (RiPPs) catalyze the cleavage on the precursor peptides in the biosynthesis of RiPP natural products. Here, we identified an uncharacterized serine protease WprP2 from
Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan   +4 more
doaj   +1 more source

Photoinduced 1,2,3,4-tetrahydropyridine ring conversions

Beilstein Journal of Organic Chemistry, 2015
Stable heterocyclic hydroperoxide can be easily prepared as a product of fast oxidation of a 1,2,3,4-tetrahydropyridine by 3O2 if the solution is exposed to sunlight.
Baiba Turovska, Henning Lund, Viesturs Lūsis, Anna Lielpētere, Edvards Liepiņš, Sergejs Beljakovs, Inguna Goba, Jānis Stradiņš   +7 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Solvent-free, Environmentally Benign Syntheses of Some Imines and Antioxidant Activity

Orbital: The Electronic Journal of Chemistry, 2015
Environmentally benign, economically feasible, and solvent-free syntheses of series of imines by the condensation of a substituted hydroxynaphthyl ketone with several substituted iodoanilines under grinding approach are described.
Sainath B. Zangade, Avinash Shinde, Avinash Shinde, Shivaji Chavan, Shivaji Chavan, Yeshwant Vibhute, Yeshwant Vibhute   +6 more
doaj   +1 more source