Results 91 to 100 of about 4,976,102 (327)

Sustaining the Innovation Culture in SMEs: The Importance of Organisational Culture, Organisational Learning and Market Orientation

Asian Journal of Business Research, 2019
Previous research on innovation culture among SMEs has received little attention particularly in developing countries. Thus, this paper aims to investigate the influence of organisational culture, organisational learning and market orientation on ...
H. Halim, N. Ahmad, Thurasamy Ramayah
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Care: an integrated framework to support continuous, adaptable, reflective evaluation of eGovernment systems: A research note [PDF]

, 2006
CARE: an Integrated Framework to Support Continuous, Adaptable, Reflective Evaluation of Egovernment SystemsThis is an eGISE network paper. It is motivated by a concern to develop a better approach to learning from the experience of an eGovernment ...
Ah Lian, Kor, Burke, Alan, Elliman, Tony, Orange, Graham   +3 more
core   +3 more sources

The relationship between organisational culture and strategy formulation in South African firms

South African Journal of Business Management, 2002
In this article the relationship between organisational culture and strategy formulation in South African firms is investigated. The intention is to analyse whether South African firms with specific organisational culture types formulate strategies in ...
F. W. Struwig, E. E. Smith
doaj   +1 more source

Organisational culture and information systems implementation: a critical perspective [PDF]

, 2003
This research explores how information systems (IS) implementation is accomplished when cultural change of an organisation is attempted and what this accomplishment means for those touched by it.
McGrath, Kathy
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A multilevel neo-institutional analysis of infection prevention and control in English hospitals: coerced safety culture change? [PDF]

, 2019
Despite committed policy, regulative and professional efforts on healthcare safety, little is known about how such macro-interventions permeate organisations and shape culture over time.
Antonsen S., Aten K., Berger P.L., Birgand G., Boltanski L., Braithwaite J., Charani E., Charles K., Creswell J.W., Cullen W.D., Cunliffe A., Department of Health, Department of Health, Department of Health, Dixon‐Woods M., Dixon‐Woods M., Fiol C.M., Flin R., Francis R., Gioia D.A., Greenwood R., Halligan M., Harrison S.H., Hatch M.J., Herepath A., Howard‐Grenville J., Institute of Medicine (IOM), Kaufman J., Kyratsis Y., Leape L.L., Martin J., McCarthy D., Meyer J.W., Phillips N., Powell W.W., Reason J., Reay T., Reay T., Reay T., Reiman T., Schein E.H., Scott W.R., Seo M., Sexton J.B., Singer S.J., Smits M., Sorra J., Strauss A., Swidler A., Swidler A., Szymczak J.E., Templeton S.‐K., Thornton P.H., Vincent C., Walshe K., Waring J., Waring J.J., Weber K., Weick K.E., Weick K.E., Yin R.K., Zilber T.B.   +61 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

What do the CEOs’ LinkedIn posts reveal about their mindsets towards organisational culture? A discourse analysis of LinkedIn posts by the CEOs of Swedish unicorn startups

Mokslo Taikomieji Tyrimai Lietuvos Kolegijose
Over the past decade, CEOs have increasingly adopted social media as a strategic instrument to engage a broader range of stakeholders, strengthen brand visibility, drive business growth, and convey messages regarding their companies’ organisational ...
Ona Žeimytė, Giedrė Lapinskienė
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source