Results 101 to 110 of about 446,896 (309)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Cogent Business & ManagementThis study explores the influence of organisational politics on supply chain performance within the healthcare sector by focusing on the moderating roles of organisational support and transformational leadership. The study adopted a quantitative approach,
Seth Kofi Nkrumah +2 more
doaj +1 more source
Do changes in organisational status affect financial performance?
, 1990 School of ...
Parker, David
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Engineering Management in Production and ServicesHigh employee job performance is considered one of the key factors contributing to a company’s commercial success, especially in such service-oriented sectors as IT. Researchers recognise a significant role of employee organisational identification, work
Żak Katarzyna
doaj +1 more source
Fostering supply chain performance and resilience through technology
South African Journal of Business ManagementPurpose: This study aims to examine the impact of inter-organisational information and communication technology on supply chain resilience and supply chain performance.
Xiaoming Cheng
doaj +1 more source
The mediating role of organisational innovation in the relationship between strategic planning process and organisational performance in nonprofit organisations in the Kingdom of Saudi Arabia [PDF]
, 2015 Due to the increasing uncertainties and rapid changes in business environment, strategic planning has been extensively adopted in most organisations. Nowadays, nonprofit organisations also adopt strategic planning to improve their competitive advantage ...
Alshammari, Abdulsattar Mathqal
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source