Results 121 to 130 of about 8,615,313 (282)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of contextual factors on organisational performance mediated by talent management

SA Journal of Industrial Psychology
Orientation: Talent management has become a significant concept in human resource management because of the potential influence thereof on organisational performance in a competitive business environment.
Gladys B. Zake, Petronella Jonck, Anna-Marie Pelser   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

On Factors explaining Organisational Innovation and its Effects [PDF]

This paper demonstrates how various factors influence the probability of attempts at organisational innovation and the effects of such innovation. An integrated firm-level dataset obtained from two recent waves of the Norwegian Community Innovation ...
Koson Sapprasert
core  

Are the Notions of Leader–Member Exchange and Organisational Citizenship Effective in Enhancing Teachers’ Job Performance in Türkiye? A Moderated Mediation Model

Behavioral Sciences
This study is correlational and cross-sectional quantitative research that examines the moderating role of working time with the school principal on the effect of leader–member exchange on teachers’ job performance through organisational citizenship ...
Mehmet Sabir Çevik
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Transformational Leadership and Lecturer Performance: The Mediating Role of Organizational Learning and Decision-Making

Tarbawi
The main objective of this study was to examine the influence of transformational leadership, assessment, and decision-making on lecturer performance, mediated by organisational learning.
Nik Haryanti, Soebiantoro Soebiantoro, Engelien Yusniar Permanasari   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The utilisation of organisational learning capabilities for organisational sustainability [PDF]

, 2012
This research study investigates the organisational learning processes of discovery, choice and action related to organisational sustainability. In particular it investigates the Research Question ‘How do organisations utilise their organisational ...
Demetrius, David G.
core  

Examining the Mediation Effect of Anti-Citizen Behaviour in the Link Between Job Insecurity and Organizational Performance: Empirical Evidence from Tunisian Hotels

Tourism and Hospitality
Grounded in Social Exchange Theory (SET) and Conservation of Resources (COR) theory, this study tests the influence of job insecurity (JI) on organisational, particularly hotel, performance (OP) via the adoption of anti-social behaviour (ACB).
Nadir Aliane, Hassane Gharbi, Abu Elnasr E. Sobaih   +2 more
doaj   +1 more source