Results 111 to 120 of about 8,615,313 (282)

Medical leadership: boon or barrier to organisational performance? A thematic synthesis of the literature. [PDF]

BMJ Open, 2020
Savage M, Savage C, Brommels M, Mazzocato P.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Organisational identification-based model of job performance in the IT sector: mediating role of work engagement and organisational citizenship behaviour

Engineering Management in Production and Services
High employee job performance is considered one of the key factors contributing to a company’s commercial success, especially in such service-oriented sectors as IT. Researchers recognise a significant role of employee organisational identification, work
Żak Katarzyna
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Personal qualities of effective Sport Psychologists: Coping with organisational demands in high performance sport [PDF]

, 2016
The purpose of the current study was to explore colleagues’ perspectives of the personal qualities of effective sport psychologists and how these qualities enable practitioners to address the organisational demands they face within their work.
Eubank, Martin, Tod, David, Chandler, Charlotte, Cable, Tim, Nesti, Mark   +4 more
core  

Multi-perspective performance reporting and organisational performance: The impact of information, data and redundant cue load

, 2010
Multi-perspective performance reporting systems (MPRS), such as the balanced scorecard (BSC), have become popular. The BSC reports performance about four perspectives (learning and growth, internal business processes, customer and financials).
Sands, John, Iselin, Errol R., Mia, L, Mia, Lokman, Sands, J, Iselin, E R   +5 more
core   +1 more source

Fostering supply chain performance and resilience through technology

South African Journal of Business Management
Purpose: This study aims to examine the impact of inter-organisational information and communication technology on supply chain resilience and supply chain performance.
Xiaoming Cheng
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The effect of transformational leadership, organisational culture and work placement on army personnel’s work discipline and performance

SA Journal of Human Resource Management
Orientation: Personnel performance plays a crucial role in the sustainability of any organisation, including military institutions. In this context, leadership and discipline are key elements determining organisational effectiveness.
Ari Aryanto, Ahmad Alim Bachri, Ahmad Rifani, Rini Rahmawati   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source