Results 91 to 100 of about 31,091 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Psychological dynamics and organisational learning : From the dysfunctional organisation to the healthy organisation [PDF]

, 1996
This paper explores the notion of organisation health as a factor contributing to the organisation’s ability to learn and create its future. Ill health or dysfunctionality is seen as blocking learning and change.
James, Kim, Jarrett, Michael, Lucas, Donna   +2 more
core  

Тhe effects of diversity management and inclusion on organisational outcomes: a case of multinational corporation

Business: Theory and Practice, 2019
This article provides an empirical study on effects of diversity management and inclusion on organisational outcomes. The importance of diversity management and inclusion on organisation is of immense benefit especially in a Multinational Corporations ...
Folakemi Ohunakin,, Anthonia Adeniji, Olaleke Oluseye Ogunnaike, Friday Igbadume, Dayo Idowu Akintayo   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Valuing people and work in work and organisational psychology: A critical perspective on the paradoxes of meaningful work

, 2022
In questi ultimi anni, le complesse dinamiche delle trasformazioni del lavoro e delle pressioni economiche e finanziarie hanno avuto notevoli riflessi nel campo della psicologia del lavoro e delle organizzazioni in relazione al bisogno dell’individuo di soddisfare il proprio bisogno di senso.
openaire   +1 more source

Organisational variation in Recovery College implementation: 31-college qualitative study

BJPsych Open
Background By 2021, we found that 88 Recovery Colleges were operating in England. Recovery Colleges adhere to shared principles including adult education and co-production, but are also heterogeneous, varying in the populations they serve, their ...
Simran K. Takhi, Tesnime Jebara, Merly McPhilbin, Katy Stepanian, Danielle Dunnett, Jason Grant-Rowles, Yasma Osman, Gary Winship, Julie Repper, Amy Ronaldson, Mariam Namasaba, Yasuhiro Kotera, Peter Bates, Simon Lawrence, Agnieszka Kapka, Sara Meddings, Jane Rennison, Louise Patmore, Claire Henderson, Mike Slade, Simon Bishop, Vanessa Lawrence   +21 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Organisational learning: an exploration of learning strategy practices in Malaysia

, 2008
This study explores the Malaysian understanding and definition of the concept and terminology of organisational learning (OL) as well as the learning strategies and practices Malaysian organisations use to implement learning. As part of Malaysia's Vision
Arshad, Mohd Anuar
core  

Sowing the seeds of sustainability change within organisations: The importance of working the ‘social’ soil

Sustainable Futures
In response to a failure to meet global targets, sustainability goals are fast becoming a part of organisations’ responsibilities, requiring systemic transformations of people and process.
Sarah Vivienne Bentley, Cara Stitzlein, Simon Fielke   +2 more
doaj   +1 more source