Results 91 to 100 of about 378,729 (334)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organisatoriese doeltreffendheid in Suid-Afrika en Japan

SA Journal of Industrial Psychology, 1981
In different cultures various work values determine organisational practises which in turn tend to determine effectiveness. Three cultural groups namely Japanese, White South Africans and Black South Africans are compared by means of a questionnaire ...
H. I. J. Spoelstra, I. van W Raubenheimer   +1 more
doaj   +1 more source

A methodological approach to developing a measure of the psychological contract for managers [PDF]

, 2010
With a focus on a specific employment group this research attempted to add to the knowledge on the content of the psychological contract. Structured interviews with 35 managers generated 651 responses relating to the content of their psychological ...
Cable, Donald Alfred James
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organisational culture: A study of selected organisations in the manufacturing sector in the NCR

Agricultural Economics (AGRICECON), 2010
The main objective of the study is to compare the organisational culture of the selected companies in the manufacturing sector and to identify and measure the perceived organisational culture and its various dimensions.
Anu SINGH LATHER, Janos PUSKAS, Ajay KUMAr Singh, Nisha GUPTA   +3 more
doaj   +1 more source

Researching Values: Methodological Approaches for Understanding Values Work in Organisations and Leadership

, 2022
This open access book presents new approaches for researching values as they are performed or materialized. Values have been an important topic in academic literature for a long time; they are at the core of institutional theories and are often connected to ideals in organisations or ways of valuing.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cultural Orientations of sport managers [PDF]

, 2006
Various interpretations of sport management are cultural constructs underpinned by core assumptions and values held by members of professional communities. Sport managers world wide share common problems, but differ in how they resolve them.
Adler N., Azzopardi K., Berg B. L., Bloom H., Blouet B., Bobev S., Brannen M., Bryman A., Charmaz K., Chelladurai P., Chelladurai P., Chen M., Colyer S., Costa C., Darlington G., Davis K., Dayan D., Denscombe M., DeSensi J., DeSensi J., DeSensi J. T., DeSensi J. T., Dimitra Papadimitriou, Doherty A., Hall E. T., Hall E. T., Hampden-Turner C., Hampden-Turner C., Hickson D., Hickson D., Hofstede G., Hofstede G., Hofstede G., Hofstede G., Holden N., Inkeles A., Jackson R., Jackson T., Kikulis L., Kluckhohn F., Lessem R., Lewis J., Lewis R. D., Lewis R. D., Martin J., Masteralexis L., Minter R., Nicholson J., Oakley B., Palmer A., Parkhouse B., Rokeach M., Rosa López De D'Amico, Sands R., Schein E., Schneider S., Seagrave S., Slack T., Smith P., Soucie D., Taylor T., Taylor T., Taylor T., Torkildsen G., Triandis H.C., Trompenaars F., Trompenaars F., Trompenaars F., Vassil Girginov, Weese W., Westerbeek H., Willett C., Zetterholm S., Zolotov M.   +73 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source