Results 91 to 100 of about 78,797 (204)

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles

iScience
Summary: Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin to produce ceramide—a lipid influencing membrane rigidity and essential for EV generation.
Juan-Carlos A. Padilla, Seda Barutcu, Jonathan Boulais, Janaína Carla da Silva, Yiran Chen, Easin Syed, Eunjeong Kwon, Eric Lécuyer   +7 more
doaj   +1 more source

Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

iScience, 2018
Summary: Mitochondrial diseases produce profound neurological dysfunction via mutations affecting mitochondrial energy production, including the relatively common Leigh syndrome (LS).
Stephanie E. Siegmund, Robert Grassucci, Stephen D. Carter, Emanuele Barca, Zachary J. Farino, Martí Juanola-Falgarona, Peijun Zhang, Kurenai Tanji, Michio Hirano, Eric A. Schon, Joachim Frank, Zachary Freyberg   +11 more
doaj   +1 more source

Integrating Genomic Knowledge Sources through an Anatomy Ontology [PDF]

, 2004
Modern genomic research has access to a plethora of knowledge sources. Often, it is imperative that researchers combine and integrate knowledge from multiple perspectives.
Gennari, John H, Silberfein, Adam, Wiley, Jesse   +2 more
core   +1 more source

Towards physical principles of biological evolution

, 2018
Biological systems reach organizational complexity that far exceeds the complexity of any known inanimate objects. Biological entities undoubtedly obey the laws of quantum physics and statistical mechanics.
Katsnelson, Mikhail I., Koonin, Eugene V., Wolf, Yuri I.   +2 more
core   +1 more source

Pseudolycoriella hygida (Sauaia and Alves)—An Overview of a Model Organism in Genetics, with New Aspects in Morphology and Systematics

Insects
Simple Summary Pseudolycoriella hygida (Sauaia & Alves, 1968) is a lower Diptera species that belongs to the Sciaridae. This family includes about 3000 described species worldwide, including 161 in the genus Pseudolycoriella.
Frank Menzel, K. Kramp, D. Amorim, Eduardo Gorab, J. Uliana, Heni Sauaia, Nadia Monesi   +6 more
semanticscholar   +1 more source

Brain Dynamics across levels of Organization [PDF]

, 2006
After presenting evidence that the electrical activity recorded from the brain surface can reflect metastable state transitions of neuronal configurations at the mesoscopic level, I will suggest that their patterns may correspond to the distinctive ...
Werner, M.D. Gerhard
core  

Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells

iScience
Summary: Cell cycle duration heterogeneities within a malignant tumor significantly reduce the therapeutic efficacy of cancer treatment. However, identifying factors governing such heterogeneities remains challenging.
Kajal Charan, Sandip Kar
doaj   +1 more source

A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health [PDF]

, 2016
In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon ...
Allan Coukell, Carolyn Shore, Elizabeth Jungman, Kathy Talkington, Pooja Kothari, Susan K. Urahn   +5 more
core  

Multi-omics analysis of aggregative multicellularity

iScience
Summary: All organisms have to carefully regulate their gene expression, not least during development. mRNA levels are often used as proxy for protein output; however, this approach ignores post-transcriptional effects.
Bart Edelbroek, Jakub Orzechowski Westholm, Jonas Bergquist, Fredrik Söderbom   +3 more
doaj   +1 more source

Mammalian Embryology Conference: celebrating the pioneering work of Andrzej K. Tarkowski (Warsaw, Poland, 25-26 October, 2013).

International Journal of Developmental Biology, 2013
M. Krupa, Aneta Suwi
semanticscholar   +1 more source